Browsing SPH Scholarly Articles by Title

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    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...

    • Blood Donations and Risk of Coronary Heart Disease in Men 

      Ascherio, A.; Rimm, Eric; Giovannucci, E.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Stampfer, Meir (American Heart Association, 2001)
      Background-In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) ...

    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...

    • Blood Lead Levels and Major Depressive Disorder, Panic Disorder, and Generalized Anxiety Disorder in US Young Adults 

      Bouchard, Maryse F.; Bellinger, David C; Weuve, Jennifer; Matthews-Bellinger, Julia; Gilman, Stephen Edward; Wright, Robert O.; Schwartz, Joel David; Weisskopf, Marc G. (American Medical Association (AMA), 2009)
      CONTEXT: Lead is a ubiquitous neurotoxicant, and adverse cognitive and behavioral effects are well-documented in children and occupationally exposed adults but not in adults with low environmental exposure. OBJECTIVE: To ...

    • Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys 

      Fleisch, Abby F.; Burns, Jane S.; Williams, Paige L.; Lee, Mary M.; Sergeyev, Oleg; Korrick, Susan A.; Hauser, Russ (National Institute of Environmental Health Sciences, 2013)
      Background: Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort ...

    • Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study 

      Gao, Y; Baccarelli, Andrea; Shu, X O; Ji, B-T; Yu, K; Tarantini, L; Yang, G; Li, H-L; Hou, L; Rothman, N; Zheng, W; Gao, Y-T; Chow, W-H (Nature Publishing Group, 2012)
      Background: Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. However, reports on DNA methylation from a prospective study are unavailable for gastric cancer. Methods: We explored the ...

    • Blood Levels of Long-Chain Polyunsaturated Fatty Acids, Aspirin, and the Risk of Colorectal Cancer 

      Hall, M. N.; Campos, H.; Li, H.; Sesso, H. D.; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Ma, J. (American Association for Cancer Research, 2007)
      Background: N-3 fatty acids may decrease risk of colorectal cancer by inhibiting the cyclooxygenase-2 enzyme and production of proinflammatory eicosanoids derived from arachidonic acid (20:4n-6). Aspirin also inhibits the ...

    • Blood Levels of Saturated and Monounsaturated Fatty Acids as Markers of De Novo Lipogenesis and Risk of Prostate Cancer 

      Chavarro, Jorge E.; Kenfield, Stacey A.; Stampfer, Meir; Loda, Massimo; Campos, Hannia; Sesso, Howard D.; Ma, Jing (Oxford University Press, 2013)
      De novo lipogenesis has been implicated in prostate carcinogenesis, and blood levels of specific saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) could reflect activity of this pathway. We used gas ...

    • Blood Pressure Changes in Relation to Arsenic Exposure in a U.S. Pregnancy Cohort 

      Farzan, Shohreh F.; Chen, Yu; Wu, Fen; Jiang, Jieying; Liu, Mengling; Baker, Emily; Korrick, Susan A.; Karagas, Margaret R. (NLM-Export, 2015)
      Background: Inorganic arsenic exposure has been related to the risk of increased blood pressure based largely on cross-sectional studies conducted in highly exposed populations. Pregnancy is a period of particular vulnerability ...

    • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort 

      Hou, Lifang; Joyce, Brian Thomas; Gao, Tao; Liu, Lei; Zheng, Yinan; Penedo, Frank J.; Liu, Siran; Zhang, Wei; Bergan, Raymond; Dai, Qi; Vokonas, Pantel; Hoxha, Mirjam; Schwartz, Joel; Baccarelli, Andrea (Elsevier, 2015)
      Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...

    • Body Mass Index and Barrett’s Oesophagus in Women 

      Jacobson, Brian C.; Chan, Andrew T.; Giovannucci, Edward L.; Fuchs, Charles S. (BMJ Publishing Group, 2009)
      Objective: Excess body mass is associated with symptoms of gastro-oesophageal reflux disease, and cross-sectional studies suggest an association between body mass index (BMI) and Barrett's oesophagus. The present study ...

    • Body mass index and cognitive function: the potential for reverse causation 

      Suemoto, C K; Gilsanz, Paola; Mayeda, E R; Glymour, Maria Lee (Nature Publishing Group, 2015)
      Background/Objective: Higher late life body mass index (BMI) is unrelated to or even predicts lower risk of dementia in late-life, a phenomenon that may be explained by reverse causation due to weight loss during pre-clinical ...

    • Body Mass Index and Decline of Cognitive Function 

      Kim, Sujin; Kim, Yongjoo; Park, Sang Min (Public Library of Science, 2016)
      Background: The association between body mass index (BMI) and cognitive function is a public health issue. This study investigated the relationship between obesity and cognitive impairment which was assessed by the Korean ...

    • Body Mass Index and Risk of Colorectal Cancer According to Fatty Acid Synthase Expression in the Nurses’ Health Study 

      Kuchiba, Aya; Morikawa, Teppei; Yamauchi, Mai; Imamura, Yu; Liao, Xiaoyun; Chan, Andrew T.; Meyerhardt, Jeffrey A.; Giovannucci, Edward; Fuchs, Charles S.; Ogino, Shuji (Oxford University Press, 2012)
      Fatty acid synthase (FASN) plays an important role in energy metabolism of fatty acids and is overexpressed in some colon cancers. We investigated whether associations between body mass index (BMI) and risk of colorectal ...

    • Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate 

      Hanyuda, Akiko; Ogino, Shuji; Qian, Zhi Rong; Nakashima, Reiko; Song, Mingyang; Mima, Kosuke; Inamura, Kentaro; Masugi, Yohei; Wu, Kana; Meyerhardt, Jeffrey; Chan, Andrew; Fuchs, Charles S.; Giovannucci, Edward; Cao, Yin (Wiley, 2016-05-10)
      Higher body mass index (BMI), higher body adiposity, and obesity have been associated with increased risk of colorectal cancer. Evidence suggests that excess energy balance may influence systemic immune and inflammatory ...

    • Body Mass Index and Risk of Prostate Cancer in U.S. Health Professionals 

      Giovannucci, E.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Liu, Y.; Leitzmann, M.; Wu, K.; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 (Oxford University Press, 2003)
      The relationship between body mass index (BMI) and prostate cancer risk may be complex because obesity is associated with various hormonal factors and because the influence of BMI may differ according to whether the cancers ...

    • Body mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study 

      Stenholm, S.; Head, J.; Aalto, V.; Kivimäki, M.; Kawachi, I.; Zins, M.; Goldberg, M.; Platts, L.; Zaninotto, P.; Hanson, L. L. Magnusson; Westerlund, H.; Vahtera, J. (, 2017)
      BACKGROUND: While many studies have shown associations between obesity and increased risk of morbidity and mortality, little comparable information is available on how body mass index (BMI) impacts health expectancy. We ...

    • Body mass index before and after breast cancer diagnosis: Associations with all-cause, breast cancer, and cardiovascular disease mortality 

      Nichols, Hazel B.; Trentham-Dietz, Amy; Egan, Kathleen M.; Titus-Ernstoff, Linda; Holmes, Michelle D.; Bersch, Andrew J.; Holick, Crystal N.; Hampton, John M.; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Newcomb, Polly A. (American Association for Cancer Research, 2009)
      Background: Factors related to improving outcomes in breast cancer survivors are of increasing public health significance. We examined postdiagnosis weight change in relation to mortality risk in a cohort of breast cancer ...

    • Body Mass Index Genetic Risk Score and Endometrial Cancer Risk 

      Prescott, Jennifer; Setiawan, Veronica W.; Wentzensen, Nicolas; Schumacher, Fredrick; Yu, Herbert; Delahanty, Ryan; Bernstein, Leslie; Chanock, Stephen J.; Chen, Chu; Cook, Linda S.; Friedenreich, Christine; Garcia-Closas, Monserrat; Haiman, Christopher A.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Olson, Sara H.; Risch, Harvey A.; Shu, Xiao-Ou; Ursin, Giske; Yang, Hannah P.; Kraft, Peter; De Vivo, Immaculata (Public Library of Science, 2015)
      Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) ...

    • Body Mass Index in Young Adulthood, Obesity Trajectory, and Premature Mortality 

      Hirko, Kelly; Kantor, Elizabeth; Cohen, Sarah; Blot, William; Stampfer, Meir; Signorello, Lisa (Oxford University Press, 2015)
      Although much research has been conducted on the role adult body mass index (BMI) plays in mortality, there have been fewer studies that evaluated the associations of BMI in young adulthood and adult weight trajectory with ...