Browsing SPH Scholarly Articles by Title

Now showing items 968-987 of 6362

    • Cell type-specific DNA methylation patterns in the human breast 

      Bloushtain-Qimron, Noga; Yao, Jun; Snyder, Eric L.; Shipitsin, Michail; Campbell, Lauren L.; Mani, Sendurai A.; Hu, Min; Chen, Haiyan; Ustyansky, Vadim; Antosiewicz, Jessica E.; Argani, Pedram; Halushka, Marc K.; Thomson, James A.; Pharoah, Paul; Porgador, Angel; Sukumar, Saraswati; Parsons, Ramon; Richardson, Andrea L.; Stampfer, Martha R.; Gelman, Rebecca S.; Nikolskaya, Tatiana; Nikolsky, Yuri; Polyak, Kornelia (National Academy of Sciences, 2008)
      Cellular identity and differentiation are determined by epigenetic programs. The characteristics of these programs in normal human mammary epithelium and their similarity to those in stem cells are unknown. To begin ...

    • CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types 

      Nelms, Bradlee D.; Waldron, Levi; Barrera, Luis A.; Weflen, Andrew W.; Goettel, Jeremy A.; Guo, Guoji; Montgomery, Robert K.; Neutra, Marian R.; Breault, David T.; Snapper, Scott B.; Orkin, Stuart H.; Bulyk, Martha L.; Huttenhower, Curtis; Lencer, Wayne I. (BioMed Central, 2016)
      We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our ...

    • Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh 

      Bhuiyan, Saruar; Sayeed, Abu; Khanam, Farhana; Leung, Daniel T.; Rahman Bhuiyan, Taufiqur; Sheikh, Alaullah; Salma, Umme; LaRocque, Regina C.; Harris, Jason B.; Pacek, Marcin; Calderwood, Stephen B.; LaBaer, Joshua; Ryan, Edward T.; Qadri, Firdausi; Charles, Richelle C. (The American Society of Tropical Medicine and Hygiene, 2014)
      We assessed interferon-gamma (IFN-γ) responses via enzyme-linked immunosorbent spot (ELISPOT) to a number of S. Typhi antigens in samples from humans with S. Typhi bacteremia and typhoid fever in Bangladesh. Compared with ...

    • Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study 

      Chuang, Shu-Chun; Boeing, Heiner; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Bueno-de-Mesquita, Bas; Lajous, Martin; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Küehn, Tilman; Pischon, Tobias; Drogan, Dagmar; Tjønneland, Anne; Overvad, Kim; Quirós, J Ramón; Agudo, Antonio; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J.; Travis, Ruth C.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H; Weiderpass, Elisabete; Palmqvist, Richard; Ljuslinder, Ingrid; Gunter, Marc; Lu, Yunxia; Cross, Amanda J.; Riboli, Elio; Vineis, Paolo; Aleksandrova, Krasimira (BioMed Central, 2016)
      Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). ...

    • Central adiposity, regional fat distribution, and the risk of cholecystectomy in women 

      Tsai, C-J.; Leitzmann, M. F.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Giovannucci, E. L. (BMJ Publishing Group, 2006)
      Purpose: Whether central adiposity contributes independently of total adiposity to the risk for gall stones is inconclusive. We examined prospectively indicators of central adiposity in relation to the occurrence of gall ...

    • Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6 

      Min, Yoon; Wi, Sae Mi; Kang, Jung-Ah; Yang, Taewoo; Park, Chul-Seung; Park, Sung-Gyoo; Chung, Sungkwon; Shim, Jae-Hyuck; Chun, Eunyoung; Lee, Ki-Young (Nature Publishing Group, 2016)
      Cereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. CRBN overexpression leads to suppression of NF-κB ...

    • Cervical Cancer Epidemiology Among HIV-Infected Women in North America 

      D’Souza, Gypsyamber; Jing, Yuezhou; Strickler, Howard; Silverberg, Michael; Engels, Eric; Dubrow, Robert; Eron, Joseph; Gebo, Kelly; Hogg, Bob; Kitahata, Mari; Klein, Marina; Moore, Richard; Rourke, Sean; Abraham, Alison G; Bosch, Ronald J.; Brooks, John T.; Gill, M J (BioMed Central, 2010)

    • Cervical cancer risk factors among HIV-infected Nigerian women 

      Ononogbu, Uzoma; Almujtaba, Maryam; Modibbo, Fatima; Lawal, Ishak; Offiong, Richard; Olaniyan, Olayinka; Dakum, Patrick; Spiegelman, Donna; Blattner, William; Adebamowo, Clement (BioMed Central, 2013)
      Background: Cervical cancer is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Cervical cancer is an AIDS-defining cancer; however, HIV only marginally increases ...

    • Cessation Among Smokers of “Light” Cigarettes: Results From the 2000 National Health Interview Survey 

      Tindle, Hilary A.; Rigotti, Nancy A.; Davis, Roger B.; Barbeau, Elizabeth M.; Kawachi, Ichiro; Shiffman, Saul (Elsevier BV, 2006)
      Objectives. A large proportion of smokers erroneously believe that low-nicotine/low-tar cigarettes, also called "light cigarettes" or "lights," reduce health risks and are a rational alternative to smoking cessation. ...

    • CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data 

      McGeachie, Michael J.; Chang, Hsun-Hsien; Weiss, Scott T. (Public Library of Science, 2014)
      Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous ...

    • Challenges and opportunities experienced by performing artists during COVID-19 lockdown: Scoping review 

      Brooks, Samantha K.; Patel, Sonny (Elsevier BV, 2022)
      Highlights • Performing artists experienced loss of work, income, and social connections. • Some experienced negative psychological effects as a result. • Many also reported exploring new avenues and shifting to remote ...

    • Challenges and opportunities in establishing a collaborative multisite observational study of chronic diseases and lifestyle factors among adults in Puerto Rico 

      Mattei, Josiemer; Rodríguez-Orengo, José F.; Tamez, Martha; Corujo, Francheska; Claudio, Aida; Villanueva, Héctor; Campos, Hannia; Willett, Walter C.; Tucker, Katherine L.; Ríos-Bedoya, Carlos F. (Springer Nature, 2017)
      Background Prevalence of chronic diseases and unhealthy lifestyle behaviors among the adult population of Puerto Rico (PR) is high; however, few epidemiological studies have been conducted to address these. We aimed to ...

    • Challenges for malaria elimination in Brazil 

      Ferreira, Marcelo U.; Castro, Marcia C. (BioMed Central, 2016)
      Brazil currently contributes 42 % of all malaria cases reported in the Latin America and the Caribbean, a region where major progress towards malaria elimination has been achieved in recent years. In 2014, malaria burden ...

    • Challenges in global improvement of oral cancer outcomes: findings from rural Northern India 

      Dangi, Jyoti; Kinnunen, Taru Hannele; Zavras, Athanasios I. (BioMed Central, 2012)
      Background: In India, 72% of the population resides in rural areas and 30-40% of cancers are found in the oral cavity. The majority of Haryana residents live in villages where inadequate medical facilities, no proper primary ...

    • Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection 

      Sailasuta, Napapon; Ross, William; Ananworanich, Jintanat; Chalermchai, Thep; De Gruttola, Victor Gerard; Lerdlum, Sukalaya; Pothisri, Mantana; Busovaca, Edgar; Ratto-Kim, Silvia; Jagodzinski, Linda; Spudich, Serena; Michael, Nelson; Kim, Jerome H.; Valcour, Victor (Public Library of Science, 2012)
      Objective: Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain ...

    • Change in Brainstem Gray Matter Concentration Following a Mindfulness-Based Intervention is Correlated with Improvement in Psychological Well-Being 

      Singleton, Omar; Hölzel, Britta K.; Vangel, Mark; Brach, Narayan; Carmody, James; Lazar, Sara W. (Frontiers Media S.A., 2014)
      Individuals can improve their levels of psychological well-being (PWB) through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness ...

    • Change in neighborhood disadvantage and change in smoking behaviors in adults: a longitudinal, within-individual study 

      Halonen, Jaana; Pulakka, Anna; Stenholm, Sari; Pentti, Jaana; Kawachi, Ichiro; Kivimäki, Mika; Vahtera, Jussi (, 2016)
      Background: Evidence for an association between neighborhood disadvantage and smoking is mixed and mainly based on cross-sectional studies. To shed light on the causality of this association, we examined whether change in ...

    • Change in the Body Mass Index Distribution for Women: Analysis of Surveys from 37 Low- and Middle-Income Countries 

      Razak, Fahad; Corsi, Daniel J.; Subramanian, S.V. Venkata (Public Library of Science (PLoS), 2013)
      Background There are well-documented global increases in mean body mass index (BMI) and prevalence of overweight (BMI≥25.0 kg/m2) and obese (BMI≥30.0 kg/m2). Previous analyses, however, have failed to report whether ...

    • Change Point Detection in Correlation Networks 

      Barnett, Ian; Onnela, Jukka-Pekka (Nature Publishing Group, 2016)
      Many systems of interacting elements can be conceptualized as networks, where network nodes represent the elements and network ties represent interactions between the elements. In systems where the underlying network ...

    • Changes in Alcohol Consumption and Subsequent Risk of Type 2 Diabetes in Men 

      Joosten, Michel M.; Chiuve, Stephanie Elizabeth; Mukamal, Kenneth J.; Hu, Frank B.; Hendriks, Henk F. J.; Rimm, Eric B. (American Diabetes Association, 2011)
      OBJECTIVE: The objective of this study was to investigate the association of 4-year changes in alcohol consumption with a subsequent risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: We prospectively examined 38,031 ...