Browsing SPH Scholarly Articles by Title
Now showing items 3021-3040 of 6362
-
“I Always Worry about What Might Happen Ahead”: Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda
(Hindawi Publishing Corporation, 2016)Background. We explored healthcare provider perspectives and practices regarding safer conception counseling for HIV-affected clients. Methods. We conducted semistructured interviews with 38 providers (medical and clinical ... -
IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans
(NLM-Export, 2015)Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used ... -
iBBiG: iterative binary bi-clustering of gene sets
(Oxford University Press, 2012)Motivation: Meta-analysis of genomics data seeks to identify genes associated with a biological phenotype across multiple datasets; however, merging data from different platforms by their features (genes) is challenging. ... -
Identifiability, Exchangeability and Confounding revisited
(BioMed Central, 2009)In 1986 the International Journal of Epidemiology published "Identifiability, Exchangeability and Epidemiological Confounding". We review the article from the perspective of a quarter century after it was first drafted and ... -
Identification and Characterization of a Novel Association between Dietary Potassium and Risk of Crohn’s Disease and Ulcerative Colitis
(Frontiers Media S.A., 2016)Background: Recent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/TH17 pathway, which is critical in the pathogenesis of ... -
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
(2013)Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ ... -
Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry
(Oxford University Press, 2016)Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising ... -
Identification of a Rare Coding Variant in Complement 3 Associated with Age-related Macular Degeneration
(2013)Macular degeneration is a common cause of blindness in the elderly. To identify rare coding variants associated with a large increase in risk of age-related macular degeneration (AMD), we sequenced 2,335 cases and 789 ... -
Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study
(Elsevier, 2016)Purpose We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. Methods: We identified all patients (cases) with ... -
Identification of common genetic risk variants for autism spectrum disorder
(Springer Science and Business Media LLC, 2019-02-25)Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, ... -
Identification of FAM111A as an SV40 Host Range Restriction and Adenovirus Helper Factor
(Public Library of Science, 2012)The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several ... -
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
(Nature Publishing Group, 2016)Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast ... -
Identification of genes and pathways involved in kidney renal clear cell carcinoma
(BioMed Central, 2014)Background: Kidney Renal Clear Cell Carcinoma (KIRC) is one of fatal genitourinary diseases and accounts for most malignant kidney tumours. KIRC has been shown resistance to radiotherapy and chemotherapy. Like many types ... -
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis
(Elsevier, 2013)BACKGROUND and AIMS: Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis. METHODS: ... -
Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development
(eLife Sciences Publications, Ltd, 2017-09-26)The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating ... -
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
(Public Library of Science, 2014)Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, ... -
Identification of Immunogenic Salmonella enterica Serotype Typhi Antigens Expressed in Chronic Biliary Carriers of S. Typhi in Kathmandu, Nepal
(Public Library of Science, 2013)Background: Salmonella enterica serotype Typhi can colonize and persist in the biliary tract of infected individuals, resulting in a state of asymptomatic chronic carriage. Chronic carriers may act as persistent reservoirs ... -
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
(Public Library of Science, 2013)Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional ... -
Identification of New Genetic Risk Variants for Type 2 Diabetes
(Public Library of Science, 2010)Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, ... -
Identification of Nine Genomic Regions of Amplification in Urothelial Carcinoma, Correlation with Stage, and Potential Prognostic and Therapeutic Value
(Public Library of Science, 2013)We performed a genome wide analysis of 164 urothelial carcinoma samples and 27 bladder cancer cell lines to identify copy number changes associated with disease characteristics, and examined the association of amplification ...