Now showing items 3490-3509 of 6362

    • JNK1 Deficiency Does Not Enhance Muscle Glucose Metabolism in Lean Mice 

      Witczak, C.A.; Jessen, N.; Fujii, N.; Seifert, M.M.; Brandauer, J.; Hotamisligil, Gokhan; Hirshman, Michael; Goodyear, Laurie (Elsevier BV, 2006-12)
      Mice deficient in c-jun-NH2-terminal kinase 1 (JNK1) exhibit decreased fasting blood glucose and insulin levels, and protection against obesity-induced insulin resistance, suggesting increased glucose disposal into skeletal ...
    • Job strain in relation to body mass index: pooled analysis of 160,000 adults from 13 cohort studies 

      Nyberg, S T; Heikkilä, K; Fransson, E I; Alfredsson, L; De Bacquer, D; Bjorner, J B; Bonenfant, S; Borritz, M; Burr, H; Casini, A; Clays, E; Dragano, N; Erbel, R; Geuskens, G A; Goldberg, M; Hooftman, W E; Houtman, I L; Jöckel, K-H; Kittel, F; Knutsson, A; Koskenvuo, M; Leineweber, C; Lunau, T; Madsen, I E H; Hanson, L L Magnusson; Marmot, Michael Gideon; Nielsen, M L; Nordin, M; Oksanen, T; Pentti, J; Rugulies, R; Siegrist, J; Suominen, S; Vahtera, J; Virtanen, M; Westerholm, P; Westerlund, H; Zins, M; Ferrie, J E; Theorell, T; Steptoe, A; Hamer, M; Singh-Manoux, A; Batty, G D; Kivimäki, M (Blackwell Publishing Ltd, 2011)
      Background: Evidence of an association between job strain and obesity is inconsistent, mostly limited to small-scale studies, and does not distinguish between categories of underweight or obesity subclasses. Objectives: ...
    • Job Strain, Job Insecurity, and Incident Cardiovascular Disease in the Women’s Health Study: Results from a 10-Year Prospective Study 

      Slopen, Natalie; Glynn, Robert J.; Buring, Julie Elizabeth; Lewis, Tené T.; Williams, David; Albert, Michelle A. (Public Library of Science, 2012)
      Objectives: Research about work-related stressors and cardiovascular disease (CVD) has produced mixed findings. Moreover, a paucity of data exists regarding the long-term associations between job strain and job insecurity ...
    • Joint Analysis of Snp and Gene Expression Data in Genetic Association Studies of Complex Diseases 

      Huang, Yen-Tsung; VanderWeele, Tyler J.; Lin, Xihong (Institute of Mathematical Statistics, 2014)
      Genetic association studies have been a popular approach for assessing the association between common Single Nucleotide Polymorphisms (SNPs) and complex diseases. However, other genomic data involved in the mechanism from ...
    • Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations 

      Wu, Chen; Wang, Zhaoming; Song, Xin; Feng, Xiao-Shan; Abnet, Christian C.; He, Jie; Hu, Nan; Zuo, Xian-Bo; Tan, Wen; Zhan, Qimin; Hu, Zhibin; He, Zhonghu; Jia, Weihua; Zhou, Yifeng; Yu, Kai; Shu, Xiao-Ou; Yuan, Jian-Min; Zheng, Wei; Zhao, Xue-Ke; Gao, She-Gan; Yuan, Zhi-Qing; Zhou, Fu-You; Fan, Zong-Min; Cui, Ji-Li; Lin, Hong-Li; Han, Xue-Na; Li, Bei; Chen, Xi; Dawsey, Sanford M.; Liao, Linda; Lee, Maxwell P.; Ding, Ti; Qiao, You-Lin; Liu, Zhihua; Liu, Yu; Yu, Dianke; Chang, Jiang; Wei, Lixuan; Gao, Yu-Tang; Koh, Woon-Puay; Xiang, Yong-Bing; Tang, Ze-Zhong; Fan, Jin-Hu; Han, Jing-Jing; Zhou, Sheng-Li; Zhang, Peng; Zhang, Dong-Yun; Yuan, Yuan; Huang, Ying; Liu, Chunling; Zhai, Kan; Qiao, Yan; Jin, Guangfu; Guo, Chuanhai; Fu, Jianhua; Miao, Xiaoping; Lu, Changdong; Yang, Haijun; Wang, Chaoyu; Wheeler, William A.; Gail, Mitchell; Yeager, Meredith; Yuenger, Jeff; Guo, Er-Tao; Li, Ai-Li; Zhang, Wei; Li, Xue-Min; Sun, Liang-Dan; Ma, Bao-Gen; Li, Yan; Tang, Sa; Peng, Xiu-Qing; Liu, Jing; Hutchinson, Amy; Jacobs, Kevin; Giffen, Carol; Burdette, Laurie; Fraumeni, Joseph F.; Shen, Hongbing; Ke, Yang; Zeng, Yixin; Wu, Tangchun; Kraft, Peter; Chung, Charles C.; Tucker, Margaret A.; Hou, Zhi-Chao; Liu, Ya-Li; Hu, Yan-Long; Wang, Li; Yuan, Guo; Chen, Li-Sha; Liu, Xiao; Ma, Teng; Meng, Hui; Sun, Li; Li, Xin-Min; Li, Xiu-Min; Ku, Jian-Wei; Zhou, Ying-Fa; Yang, Liu-Qin; Wang, Zhou; Li, Yin; Qige, Qirenwang; Yang, Wen-Jun; Lei, Guang-Yan; Chen, Long-Qi; Li, En-Min; Yuan, Ling; Yue, Wen-Bin; Wang, Ran; Wang, Lu-Wen; Fan, Xue-Ping; Zhu, Fang-Heng; Zhao, Wei-Xing; Mao, Yi-Min; Zhang, Mei; Xing, Guo-Lan; Li, Ji-Lin; Han, Min; Ren, Jing-Li; Liu, Bin; Ren, Shu-Wei; Kong, Qing-Peng; Li, Feng; Sheyhidin, Ilyar; Wei, Wu; Zhang, Yan-Rui; Feng, Chang-Wei; Wang, Jin; Yang, Yu-Hua; Hao, Hong-Zhang; Bao, Qi-De; Liu, Bao-Chi; Wu, Ai-Qun; Xie, Dong; Yang, Wan-Cai; Wang, Liang; Zhao, Xiao-Hang; Chen, Shu-Qing; Hong, Jun-Yan; Zhang, Xue-Jun; Freedman, Neal D; Goldstein, Alisa M.; Lin, Dongxin; Taylor, Philip R.; Wang, Li-Dong; Chanock, Stephen J. (2014)
      We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and ...
    • Joint association between birth weight at term and later life adherence to a healthy lifestyle with risk of hypertension: a prospective cohort study 

      Li, Yanping; Ley, Sylvia H.; VanderWeele, Tyler J.; Curhan, Gary C.; Rich-Edwards, Janet W.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Forman, John P.; Hu, Frank B.; Qi, Lu (BMC, 2015)
      Background: Low birth weight and unhealthy lifestyles in adulthood have been independently associated with an elevated risk of hypertension. However, no study has examined the joint effects of these factors on incidence ...
    • Joint Association of Dietary Pattern and Physical Activity Level with Cardiovascular Disease Risk Factors among Chinese Men: A Cross-Sectional Study 

      Wang, Dong; He, Yuna; Li, Yanping; Luan, Dechun; Zhai, Fengying; Yang, Xiaoguang; Ma, Guansheng (Public Library of Science, 2013)
      The purpose of this cross-sectional study was to investigate the joint associations of physical activity level (PAL) and dietary patterns in relation to cardiovascular disease (CVD) risk factors among Chinese men. The study ...
    • Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women 

      Mekary, Rania A.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Giovannucci, Edward; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Ludwig, David S.; Hu, Frank B. (Oxford University Press, 2011)
      Background: Little is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). Objective: The objective of this study was to examine whether alcohol ...
    • Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk 

      Wang, Zhanwei; Risch, Harvey; Lu, Lingeng; Irwin, Melinda L.; Mayne, Susan; Schwartz, Peter; Rutherford, Thomas; De Vivo, Immaculata; Yu, Herbert (Nature Publishing Group, 2015)
      Prolonged estrogen exposure is believed to be the major cause of endometrial cancer. As possible markers of estrogen exposure, various menstrual and reproductive features, e.g., ages at menarche and menopause, are found ...
    • Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility 

      Fang, Shenying; Han, Jiali; Zhang, Mingfeng; Wang, Li-e; Wei, Qingyi; Amos, Christopher I.; Lee, Jeffrey E. (Public Library of Science, 2013)
      Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ...
    • Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer 

      Hiraki, Linda T.; Joshi, Amit D.; Ng, Kimmie; Fuchs, Charles S.; Ma, Jing; Hazra, Aditi; Peters, Ulrike; Karlson, Elizabeth W.; Giovannucci, Edward; Kraft, Peter; Chan, Andrew T. (Public Library of Science, 2014)
      Background: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. Methods: We examined main and ...
    • Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases 

      McGeachie, Michael John; Clemmer, George L.; Lasky-Su, Jessica A. Lasky; Dahlin, Amber Aziza; Raby, Benjamin Alexander; Weiss, Scott Tillman (Elsevier BV, 2014)
      We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method ...
    • The Joint Impact on Being Overweight of Self Reported Behaviours of Eating Quickly and Eating until Full: Cross Sectional Survey 

      Maruyama, Koutatsu; Sato, Shinichi; Ohira, Tetsuya; Maeda, Kenji; Kubota, Yoshimi; Nishimura, Setsuko; Kitamura, Akihiko; Kiyama, Masahiko; Okada, Takeo; Imano, Hironori; Nakamura, Masakazu; Ishikawa, Yoshinori; Kurokawa, Michinori; Sasaki, Satoshi; Iso, Hiroyasu; Noda, Hiroyuki (BMJ Publishing Group Ltd., 2008)
      Objective: To examine whether eating until full or eating quickly or combinations of these eating behaviours are associated with being overweight. Design and participants: Cross sectional survey. Setting: Two communities ...
    • Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis 

      Boundy, Ellen; Dastjerdi, Roya; Spiegelman, Donna; Fawzi, Wafaie; Missmer, Stacey; Lieberman, Ellice; Kajeepeta, Sandhya; Wall, Stephen; Chan, Grace (American Academy of Pediatrics, 2016)
      CONTEXT: Kangaroo mother care (KMC) is an intervention aimed at improving outcomes among preterm and low birth weight newborns. Objective: Conduct a systematic review and meta-analysis estimating the association between ...
    • Kangaroo mother care: a systematic review of barriers and enablers 

      Chan, Grace J; Labar, Amy S; Wall, Stephen; Atun, Rifat (World Health Organization, 2016)
      Abstract Objective: To investigate factors influencing the adoption of kangaroo mother care in different contexts. Methods: We searched PubMed, Embase, Scopus, Web of Science and the World Health Organization’s regional ...
    • Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study 

      Chipps, Bradley E.; Zeiger, Robert S.; Borish, Larry; Wenzel, Sally E.; Yegin, Ashley; Hayden, Mary Lou; Miller, Dave P.; Bleecker, Eugene R.; Simons, F. Estelle R.; Szefler, Stanley J.; Weiss, Scott Tillman; Haselkorn, Tmirah (Elsevier BV, 2012)
      Patients with severe or difficult-to-treat asthma are an understudied population but account for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural History of Asthma: Outcomes and Treatment ...
    • Key Findings on Alcohol Consumption and a Variety of Health Outcomes From the Nurses’ Health Study 

      Mostofsky, Elizabeth; Mukamal, Kenneth; Giovannucci, Ed; Stampfer, Meir; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (American Public Health Association, 2016)
      Objectives. To review critical contributions from the Nurses' Health Study (NHS) on alcohol consumption and health outcomes.Methods. We performed a narrative review of NHS (1980-2012) and NHS II (1989-2011) publications.Results. ...
    • Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study 

      Kurth, Tobias; de Jong, Paul E; Cook, Nancy Romanowicz; Buring, Julie Elizabeth; Ridker, Paul M. (BMJ Publishing Group Ltd., 2009)
      Objective: To evaluate the association of kidney function with cardiovascular disease and mortality among apparently healthy women. Design: Prospective cohort study. Setting: Women’s Health Study, United States. Participants: ...
    • Killer Cell Immunoglobulin-Like Receptor Alleles Alter HIV Disease in Children 

      Singh, Kumud K.; Qin, Min; Brummel, Sean S.; Angelidou, Konstantia; Trout, Rodney N.; Fenton, Terence; Spector, Stephen A. (Public Library of Science, 2016)
      Background: HLA class I molecules are ligands for killer cell immunoglobin like receptors (KIR) that control the antiviral response of natural killer (NK) cells. However, the effects of KIR and HLA (KIR/HLA) alleles on HIV ...
    • Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy 

      Kuijjer, Marieke L; van den Akker, Brendy EWM; Hilhorst, Riet; Mommersteeg, Monique; Buddingh, Emilie P; Serra, Massimo; Bürger, Horst; Hogendoorn, Pancras CW; Cleton-Jansen, Anne-Marie (BioMed Central, 2014)
      Background: High-grade osteosarcoma is a primary malignant bone tumor mostly occurring in adolescents and young adults, with a second peak at middle age. Overall survival is approximately 60%, and has not significantly ...