Now showing items 4337-4356 of 6362

    • P09-11. Reduced Replication Capacity of NL4-3 Chimeric Viruses Encoding RT-Integrase Sequences from HIV-1 Elite Controllers 

      Brumme, ZL; Miura, T; Rosato, PC; Sela, J; Brumme, CJ; Heckerman, D; Walker, BD; Brockman, Mark; Pereyra, Florencia M.; Li, C (BioMed Central, 2009)
      Background: Spontaneous control of HIV to <50 copies RNA/ml is observed in rare individuals. An improved understanding of this phenomenon may provide insight into host mechanisms that can be modulated for therapeutic benefit ...
    • P09-20 LB. Ultra-Deep Sequencing of Full-Length HIV-1 Genomes Identifies Rapid Viral Evolution During Acute Infection 

      Henn, MR; Lennon, N; Malboeuf, C; Charlebois, P; Philips, L; Berical, A; Erlich, R; Kemper, M; Axten, K; Brumme, Z; Brumme, C; Jessen, H; Nusbaum, C; Birren, B; Allen, TM; Boutwell, Christian Lane; Power, K; Gladden, Andrew B; Levin, Jonathan M.; Casali, Monica; Berlin, A; Anderson, S; Streeck, Hendrik; Ryan, Edward Thomas; Wang, Y; Green, L; Russ, Christiana Marie; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (BioMed Central, 2009)
    • P16-08. Combined blockade of the PD-1 and IL-10 pathways synergistically enhance HIV-specific CD4 T cell functions 

      Porichis, Filippos; Kwon, DS; Tighe, DP; Pavlik, DF; Kavanagh, Daniel Garrett; Freeman, Gordon James; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2009)
    • P16-12. Relative Dominance of Gag-Specific Cytotoxic T Lymphocytes Is Associated with Viral Load Inversely in HIV-1 Clade B' Infected Chinese 

      Jia, M; Chen, J; Hong, K; Liu, S; Zhang, X; Zhao, H; Altfeld, Marcus; Walker, Bruce David; Yu, Xu; Shao, Y (BioMed Central, 2009)
    • P16-18. Regulatory T Cell Frequencies Correlate With T Cell Activation in Chronic HIV-1 Infection 

      Pyo, A; Trocha, A; Toth, I; Addo, MM; Angin, Mathieu; Streeck, Hendrik; Pereyra, Florencia M.; Walker, Bruce David; Altfeld, Marcus; Alter, G; Kwon, D; Wen, F (BioMed Central, 2009)
    • P16-31. Skewed HIV-1-Specific CD4+ Th2 Helper Cell Contribution in Progressive HIV-1 Infection 

      Chevalier, M; Pyo, A; Jolin, J. S.; Addo, Marylyn Martina; Kwon, DS; Toth, I; Walker, Bruce David; Streeck, Hendrik (BioMed Central, 2009)
    • P20-12. Heterogeneity of Gag Mutational Pathways in Primary HIV-1 Subtype C Infection 

      Lagakos, S; Kebaabetswe, L; Rossenkhan, R; Woldegabriel, E; van Widenfelt, E; Novitsky, Vladimir A.; Wang, Richard Yun; Margolin, Lauren; Baca, Jeannie; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Essex, Myron Elmer (BioMed Central, 2009)
      Poster presentation
    • p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming 

      Gong, Lu; Pan, Xiao; Chen, Haide; Rao, Lingjun; Zeng, Yelin; Hang, Honghui; Peng, Jinrong; Xiao, Lei; Chen, Jun (Nature Publishing Group, 2016)
      Human induced pluripotent stem (iPS) cells have great potential in regenerative medicine, but this depends on the integrity of their genomes. iPS cells have been found to contain a large number of de novo genetic alterations ...
    • p63 promotes cell survival through fatty acid synthase 

      Sabbisetti, Venkata S; Di Napoli, Arianna; Seeley, Apryle; Amato, Angela M.; O'Regan, Esther; Ghebremichael, Musie Syum; Loda, Massimo; Signoretti, Sabina (Public Library of Science, 2009)
      There is increasing evidence that p63, and specifically ΔNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival. However, few studies have addressed the molecular mechanisms ...
    • Packaging health services when resources are limited: the example of a cervical cancer screening visit 

      Kim, Jane Jooyun; Salomon, Joshua A.; Weinstein, Milton C.; Goldie, Sue J. (Public Library of Science, 2006)
      Background: Increasing evidence supporting the value of screening women for cervical cancer once in their lifetime, coupled with mounting interest in scaling up successful screening demonstration projects, present challenges ...
    • Pain management among Dominican patients with advanced osteoarthritis: a qualitative study 

      Yu, Amy; Devine, Christopher A.; Kasdin, Rachel G.; Orizondo, Mónica; Perdomo, Wendy; Davis, Aileen M.; Bogart, Laura M.; Katz, Jeffrey N. (BioMed Central, 2016)
      Background: Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission ...
    • Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma 

      Stachler, Matthew D.; Taylor-Weiner, Amaro; Peng, Shouyong; McKenna, Aaron; Agoston, Agoston T.; Odze, Robert D.; Davison, Jon M.; Nason, Katie S.; Loda, Massimo; Leshchiner, Ignaty; Stewart, Chip; Stojanov, Petar; Seepo, Sara; Lawrence, Michael S.; Ferrer-Torres, Daysha; Lin, Jules; Chang, Andrew C.; Gabriel, Stacey B.; Lander, Eric S.; Beer, David G.; Getz, Gad; Carter, Scott L.; Bass, Adam J. (2015)
      Barrett’s esophagus, is thought to progress to esophageal adenocarcinoma (EAC) through a step-wise progression with loss of CDKN2A followed by p53 inactivation and aneuploidy. Here, we present whole exome sequencing from ...
    • Pairwise diversity and tMRCA as potential markers for HIV infection recency 

      Moyo, Sikhulile; Wilkinson, Eduan; Vandormael, Alain; Wang, Rui; Weng, Jia; Kotokwe, Kenanao; Gaseitsiwe, Simani; Musonda, Rosemary; Makhema, Joseph; Essex, Max; Engelbrecht, Susan; de Oliveira, Tulio; Novitsky, Vladimir (Public Library of Science, 2017)
      Intrahost human immunodeficiency virus (HIV)-1 diversity increases linearly over time. We assessed the extent to which mean pairwise distances and the time to the most recent common ancestor (tMRCA) inferred from intrahost ...
    • Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer 

      Bowman-Colin, Christian; Xia, B.; Bunting, S.; Klijn, C.; Drost, R.; Bouwman, P.; Fineman, L.; Chen, X.; Culhane, Aedin; Cai, H.; Rodig, Scott J.; Bronson, Roderick Terry; Jonkers, J.; Nussenzweig, A.; Kanellopoulou, C.; Livingston, David Morse (Proceedings of the National Academy of Sciences, 2013)
      Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS 

      Southey, Melissa C; Goldgar, David E; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William D; Dennis, Joe; Michailidou, Kyriaki; van Rensburg, Elizabeth J; Heikkinen, Tuomas; Nevanlinna, Heli; Hopper, John L; Dörk, Thilo; Claes, Kathleen BM; Reis-Filho, Jorge; Teo, Zhi Ling; Radice, Paolo; Catucci, Irene; Peterlongo, Paolo; Tsimiklis, Helen; Odefrey, Fabrice A; Dowty, James G; Schmidt, Marjanka K; Broeks, Annegien; Hogervorst, Frans B; Verhoef, Senno; Carpenter, Jane; Clarke, Christine; Scott, Rodney J; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Peto, Julian; dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federik; Burwinkel, Barbara; Yang, Rongxi; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig; Nielsen, Sune F; Flyger, Henrik; Benitez, Javier; Zamora, M Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan; Ziogas, Argyrios; Clarke, Christina A; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Spurdle, Amanda B; Wauters, Els; Smeets, Dominiek; Beuselinck, Benoit; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Olson, Janet E; Vachon, Celine; Pankratz, Vernon S; McLean, Catriona; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Kristensen, Vessela; Alnæs, Grethe Grenaker; Zheng, Wei; Hunter, David J; Lindstrom, Sara; Hankinson, Susan E; Kraft, Peter; Andrulis, Irene; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Jukkola-Vuorinen, Arja; Grip, Mervi; Kauppila, Saila; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Hollestelle, Antoinette; Garcia-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Eccles, Diana M; Rafiq, Sajjad; Tapper, William J; Gerty, Sue M; Hooning, Maartje J; Martens, John W M; Collée, J Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Cox, Angela; Reed, Malcolm W R; Luccarini, Craig; Baynes, Caroline; Dunning, Alison M; Hamann, Ute; Torres, Diana; Ulmer, Hans Ulrich; Rüdiger, Thomas; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E; Ambrosone, Christine B; Yannoukakos, Drakoulis; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Simard, Jacques; Dumont, Martine; Soucy, Penny; Eeles, Rosalind; Muir, Kenneth; Wiklund, Fredrik; Gronberg, Henrik; Schleutker, Johanna; Nordestgaard, Børge G; Weischer, Maren; Travis, Ruth C; Neal, David; Donovan, Jenny L; Hamdy, Freddie C; Khaw, Kay-Tee; Stanford, Janet L; Blot, William J; Thibodeau, Stephen; Schaid, Daniel J; Kelley, Joseph L; Maier, Christiane; Kibel, Adam S; Cybulski, Cezary; Cannon-Albright, Lisa; Butterbach, Katja; Park, Jong; Kaneva, Radka; Batra, Jyotsna; Teixeira, Manuel R; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Benlloch, Sara; Renner, Stefan P; Hartmann, Arndt; Hein, Alexander; Ruebner, Matthias; Lambrechts, Diether; Van Nieuwenhuysen, Els; Vergote, Ignace; Lambretchs, Sandrina; Doherty, Jennifer A; Rossing, Mary Anne; Nickels, Stefan; Eilber, Ursula; Wang-Gohrke, Shan; Odunsi, Kunle; Sucheston-Campbell, Lara E; Friel, Grace; Lurie, Galina; Killeen, Jeffrey L; Wilkens, Lynne R; Goodman, Marc T; Runnebaum, Ingo; Hillemanns, Peter A; Pelttari, Liisa M; Butzow, Ralf; Modugno, Francesmary; Edwards, Robert P; Ness, Roberta B; Moysich, Kirsten B; du Bois, Andreas; Heitz, Florian; Harter, Philipp; Kommoss, Stefan; Karlan, Beth Y; Walsh, Christine; Lester, Jenny; Jensen, Allan; Kjaer, Susanne Krüger; Høgdall, Estrid; Peissel, Bernard; Bonanni, Bernardo; Bernard, Loris; Goode, Ellen L; Fridley, Brooke L; Vierkant, Robert A; Cunningham, Julie M; Larson, Melissa C; Fogarty, Zachary C; Kalli, Kimberly R; Liang, Dong; Lu, Karen H; Hildebrandt, Michelle A T; Wu, Xifeng; Levine, Douglas A; Dao, Fanny; Bisogna, Maria; Berchuck, Andrew; Iversen, Edwin S; Marks, Jeffrey R; Akushevich, Lucy; Cramer, Daniel W; Schildkraut, Joellen; Terry, Kathryn L; Poole, Elizabeth M; Stampfer, Meir; Tworoger, Shelley S; Bandera, Elisa V; Orlow, Irene; Olson, Sara H; Bjorge, Line; Salvesen, Helga B; van Altena, Anne M; Aben, Katja K H; Kiemeney, Lambertus A; Massuger, Leon F A G; Pejovic, Tanja; Bean, Yukie; Brooks-Wilson, Angela; Kelemen, Linda E; Cook, Linda S; Le, Nhu D; Górski, Bohdan; Gronwald, Jacek; Menkiszak, Janusz; Høgdall, Claus K; Lundvall, Lene; Nedergaard, Lotte; Engelholm, Svend Aage; Dicks, Ed; Tyrer, Jonathan; Campbell, Ian; McNeish, Iain; Paul, James; Siddiqui, Nadeem; Glasspool, Rosalind; Whittemore, Alice S; Rothstein, Joseph H; McGuire, Valerie; Sieh, Weiva; Cai, Hui; Shu, Xiao-Ou; Teten, Rachel T; Sutphen, Rebecca; McLaughlin, John R; Narod, Steven A; Phelan, Catherine M; Monteiro, Alvaro N; Fenstermacher, David; Lin, Hui-Yi; Permuth, Jennifer B; Sellers, Thomas A; Chen, Y Ann; Tsai, Ya-Yu; Chen, Zhihua; Gentry-Maharaj, Aleksandra; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Wu, Anna H; Pearce, Celeste L; Van Den Berg, David; Pike, Malcolm C; Dansonka-Mieszkowska, Agnieszka; Plisiecka-Halasa, Joanna; Moes-Sosnowska, Joanna; Kupryjanczyk, Jolanta; Pharoah, Paul DP; Song, Honglin; Winship, Ingrid; Chenevix-Trench, Georgia; Giles, Graham G; Tavtigian, Sean V; Easton, Doug F; Milne, Roger L (2016)
      Background: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
    • Pancreatic cancer risk associated with prediagnostic plasma levels of leptin and leptin receptor genetic polymorphisms 

      Babic, Ana; Bao, Ying; Qian, Zhi Rong; Yuan, Chen; Giovannucci, Edward; Aschard, Hugues; Kraft, Peter; Amundadottir, Laufey; Stolzenberg-Solomon, Rachael; Morales-Oyarvide, Vicente; Ng, Kimmie; Stampfer, Meir; Ogino, Shuji; Buring, Julie; Sesso, Howard; Gaziano, John Michael; Rifai, Nader; Pollak, Michael; Anderson, Matthew; Cochrane, Barbara; Luo, Juhua; Manson, JoAnn; Fuchs, Charles; Wolpin, Brian (American Association for Cancer Research, 2016)
      Leptin is an adipokine involved in regulating energy balance, which has been identified as a potential biologic link in the development of obesity-associated cancers, such as pancreatic cancer. In this prospective, nested ...
    • Pandemic Influenza: Risk of Multiple Introductions and the Need to Prepare for Them 

      Mills, Christina E; Robins, James M.; Bergstrom, Carl T; Lipsitch, Marc (Public Library of Science (PLoS), 2006)
    • A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders 

      Kile, Molly L; Fang, Shona; Baccarelli, Andrea A; Tarantini, Letizia; Cavallari, Jennifer; Christiani, David C (BioMed Central, 2013)
      Background: Exposure to pollutants including metals and particulate air pollution can alter DNA methylation. Yet little is known about intra-individual changes in DNA methylation over time in relationship to environmental ...
    • Paracelsus Revisited: The Dose Concept in a Complex World 

      Grandjean, Philippe (Wiley-Blackwell, 2016)
      At the time that Paracelsus coined his famous dictum, “What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison,” embryonic toxicology ...