Now showing items 5765-5784 of 6362

    • T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis 

      Kim, Gloria; Khalid, Fariha; Oommen, Vinit V.; Tauhid, Shahamat; Chu, Renxin; Horsfield, Mark A.; Healy, Brian C.; Bakshi, Rohit (BioMed Central, 2015)
      Background: The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). Methods: We compared T1- and T2-weighted MRI for measuring ...
    • Tablet Keyboard Configuration Affects Performance, Discomfort and Task Difficulty for Thumb Typing in a Two-Handed Grip 

      Trudeau, Matthieu B.; Catalano, Paul J.; Jindrich, Devin L.; Dennerlein, Jack T. (Public Library of Science, 2013)
      When holding a tablet computer with two hands, the touch keyboard configuration imposes postural constraints on the user because of the need to simultaneously hold the device and type with the thumbs. Designers have provided ...
    • Tai Chi for Osteopenic Women: Design and Rationale of a Pragmatic Randomized Controlled Trial 

      Wayne, Peter Michael; Buring, Julie Elizabeth; Davis, Roger B.; Connors, Ellen M; Bonato, Paolo; Patritti, Benjamin Lorenzo; Fischer, Mary; Yeh, Gloria Y.; Cohen, Calvin Jay; Carroll, Danette; Kiel, Douglas P. (BioMed Central, 2010)
      Background: Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density ...
    • Tai chi mind-body exercise in patients with COPD: study protocol for a randomized controlled trial 

      Yeh, Gloria Y; Wayne, Peter M; Litrownik, Daniel; Roberts, David H; Davis, Roger B; Moy, Marilyn L (BioMed Central, 2014)
      Background: Chronic obstructive pulmonary disease (COPD) is a chronic, progressively debilitating condition that is prevalent in the US and worldwide. Patients suffer from progressive dyspnea and exercise intolerance. ...
    • Tai Chi Training may Reduce Dual Task Gait Variability, a Potential Mediator of Fall Risk, in Healthy Older Adults: Cross-Sectional and Randomized Trial Studies 

      Wayne, Peter M.; Hausdorff, Jeffrey M.; Lough, Matthew; Gow, Brian J.; Lipsitz, Lewis; Novak, Vera; Macklin, Eric A.; Peng, Chung-Kang; Manor, Brad (Frontiers Media S.A., 2015)
      Background: Tai Chi (TC) exercise improves balance and reduces falls in older, health-impaired adults. TC’s impact on dual task (DT) gait parameters predictive of falls, especially in healthy active older adults, however, ...
    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...
    • Take the money and run? Redemption of a gift card incentive in a clinician survey 

      Chen, Jane S.; Sprague, Brian L.; Klabunde, Carrie N.; Tosteson, Anna N. A.; Bitton, Asaf; Onega, Tracy; MacLean, Charles D.; Harris, Kimberly; Schapira, Marilyn M.; Haas, Jennifer S. (BioMed Central, 2016)
      Background: Clinician surveys provide critical information about many facets of health care, but are often challenging to implement. Our objective was to assess use by participants and non-participants of a prepaid gift ...
    • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 

      Tin, Adrienne; Marten, Jonathan; Halperin Kuhns, Victoria L.; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B.; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y.; Hoppmann, Anselm; O'Connor, Luke; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato; Cocca, Massimiliano; Ghasemi, Sahar; van der Most, Peter J.; Horn, Katrin; Xu, Yizhe; Fuchsberger, Christian; Sedaghat, Sanaz; Afaq, Saima; Amin, Najaf; Ärnlöv, Johan; Bakker, Stephan J. L.; Bansal, Nisha; Baptista, Daniela; Bergmann, Sven; Biggs, Mary L.; Biino, Ginevra; Boerwinkle, Eric; Bottinger, Erwin P.; Boutin, Thibaud S.; Brumat, Marco; Burkhardt, Ralph; Campana, Eric; Campbell, Archie; Campbell, Harry; Carroll, Robert J.; Catamo, Eulalia; Chambers, John C.; Ciullo, Marina; Concas, Maria Pina; Coresh, Josef; Corre, Tanguy; Cusi, Daniele; Felicita, Sala Cinzia; de Borst, Martin H.; De Grandi, Alessandro; de Mutsert, Renée; de Vries, Aiko P. J.; Delgado, Graciela; Demirkan, Ayşe; Devuyst, Olivier; Dittrich, Katalin; Eckardt, Kai-Uwe; Ehret, Georg; Endlich, Karlhans; Evans, Michele K.; Gansevoort, Ron T.; Gasparini, Paolo; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Gögele, Martin; Gordon, Scott D.; Gudbjartsson, Daniel F.; Gudnason, Vilmundur; Haller, Toomas; Hamet, Pavel; Harris, Tamara B.; Hayward, Caroline; Hicks, Andrew A.; Hofer, Edith; Holm, Hilma; Huang, Wei; Hutri-Kähönen, Nina; Hwang, Shih-Jen; Ikram, M. Arfan; Lewis, Raychel M.; Ingelsson, Erik; Jakobsdottir, Johanna; Jonsdottir, Ingileif; Jonsson, Helgi; Joshi, Peter K.; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Kamatani, Yoichiro; Kanai, Masahiro; Kerr, Shona M.; Kiess, Wieland; Kleber, Marcus E.; Koenig, Wolfgang; Kooner, Jaspal S.; Körner, Antje; Kovacs, Peter; Krämer, Bernhard K.; Kronenberg, Florian; Kubo, Michiaki; Kühnel, Brigitte; La Bianca, Martina; Lange, Leslie A.; Lehne, Benjamin; Lehtimäki, Terho; Liu, Jun; Loeffler, Markus; Loos, Ruth J. F.; Lyytikäinen, Leo-Pekka; Magi, Reedik; Mahajan, Anubha; Martin, Nicholas G.; März, Winfried; Mascalzoni, Deborah; Matsuda, Koichi; Meisinger, Christa; Meitinger, Thomas; Metspalu, Andres; Milaneschi, Yuri; O'Donnell, Christopher; Wilson, Otis D.; Gaziano, John; Mishra, Pashupati P.; Mohlke, Karen L.; Mononen, Nina; Montgomery, Grant W.; Mook-Kanamori, Dennis O.; Müller-Nurasyid, Martina; Nadkarni, Girish N.; Nalls, Mike A.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Nolte, Ilja M.; Noordam, Raymond; O’Connell, Jeffrey R.; Olafsson, Isleifur; Padmanabhan, Sandosh; Penninx, Brenda W. J. H.; Perls, Thomas; Peters, Annette; Pirastu, Mario; Pirastu, Nicola; Pistis, Giorgio; Polasek, Ozren; Ponte, Belen; Porteous, David J.; Poulain, Tanja; Preuss, Michael H.; Rabelink, Ton J.; Raffield, Laura M.; Raitakari, Olli T.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Rizzi, Federica; Robino, Antonietta; Rudan, Igor; Krajcoviechova, Alena; Cifkova, Renata; Rueedi, Rico; Ruggiero, Daniela; Ryan, Kathleen A.; Saba, Yasaman; Salvi, Erika; Schmidt, Helena; Schmidt, Reinhold; Shaffer, Christian M.; Smith, Albert V.; Smith, Blair H.; Spracklen, Cassandra N.; Strauch, Konstantin; Stumvoll, Michael; Sulem, Patrick; Tajuddin, Salman M.; Teren, Andrej; Thiery, Joachim; Thio, Chris H. L.; Thorsteinsdottir, Unnur; Toniolo, Daniela; Tönjes, Anke; Tremblay, Johanne; Uitterlinden, André G.; Vaccargiu, Simona; van der Harst, Pim; van Duijn, Cornelia M.; Verweij, Niek; Völker, Uwe; Vollenweider, Peter; Waeber, Gerard; Waldenberger, Melanie; Whitfield, John B.; Wild, Sarah H.; Wilson, James F.; Yang, Qiong; Zhang, Weihua; Zonderman, Alan B.; Bochud, Murielle; Wilson, James G.; Pendergrass, Sarah A.; Ho, Kevin; Parsa, Afshin; Pramstaller, Peter P.; Psaty, Bruce M.; Böger, Carsten A.; Snieder, Harold; Butterworth, Adam S.; Okada, Yukinori; Edwards, Todd L.; Stefansson, Kari; Susztak, Katalin; Scholz, Markus; Heid, Iris M.; Hung, Adriana M.; Teumer, Alexander; Pattaro, Cristian; Woodward, Owen M.; Vitart, Veronique; Köttgen, Anna (Springer Science and Business Media LLC, 2019-10)
      Elevated serum urate levels cause gout and correlate with cardio-metabolic diseases via poorly understood mechanisms. We performed a trans-ethnic genome-wide association study of serum urate among 457,690 individuals, ...
    • Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria 

      Moreira, Wilfried; Ngan, Grace J. Y.; Low, Jian Liang; Poulsen, Anders; Chia, Brian C. S.; Ang, Melgious J. Y.; Yap, Amelia; Fulwood, Justina; Lakshmanan, Umayal; Lim, Jolander; Khoo, Audrey Y. T.; Flotow, Horst; Hill, Jeffrey; Raju, Ravikiran M.; Rubin, Eric J.; Dick, Thomas (American Society of Microbiology, 2015)
      ABSTRACT A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial ...
    • A targeted genetic association study of epithelial ovarian cancer susceptibility 

      Earp, Madalene; Winham, Stacey J.; Larson, Nicholas; Permuth, Jennifer B.; Sicotte, Hugues; Chien, Jeremy; Anton-Culver, Hoda; Bandera, Elisa V.; Berchuck, Andrew; Cook, Linda S.; Cramer, Daniel; Doherty, Jennifer A.; Goodman, Marc T.; Levine, Douglas A.; Monteiro, Alvaro N.A.; Ness, Roberta B.; Pearce, Celeste L.; Rossing, Mary Anne; Tworoger, Shelley S.; Wentzensen, Nicolas; Bisogna, Maria; Brinton, Louise; Brooks-Wilson, Angela; Carney, Michael E.; Cunningham, Julie M.; Edwards, Robert P.; Fogarty, Zachary C.; Iversen, Edwin S.; Kraft, Peter; Larson, Melissa C.; Le, Nhu D.; Lin, Hui-Yi; Lissowska, Jolanta; Modugno, Francesmary; Moysich, Kirsten B.; Olson, Sara H.; Pike, Malcolm C.; Poole, Elizabeth M.; Rider, David N.; Terry, Kathryn L.; Thompson, Pamela J.; van den Berg, David; Vierkant, Robert A.; Vitonis, Allison F.; Wilkens, Lynne R.; Wu, Anna H.; Yang, Hannah P.; Ziogas, Argyrios; Phelan, Catherine M.; Schildkraut, Joellen M.; Chen, Yian Ann; Sellers, Thomas A.; Fridley, Brooke L.; Goode, Ellen L. (Impact Journals LLC, 2016)
      Background: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate ...
    • Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget 

      Qiu, Ya-Qi; Yang, Cheng-Wei; Lee, Yue-Zhi; Yang, Ruey-Bing; Lee, Chih-Hao; Hsu, Hsing-Yu; Chang, Chien-Chung; Lee, Shiow-Ju (Impact Journals LLC, 2015)
      Tylophorine compounds have been the focus of drug development for decades. Tylophorine derivatives exhibit anti-cancer activities but their cellular targets remain unknown. We used a biotinylated tylophorine derivative to ...
    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...
    • Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma 

      Ecker, Jonas; Oehme, Ina; Mazitschek, Ralph; Korshunov, Andrey; Kool, Marcel; Hielscher, Thomas; Kiss, Judit; Selt, Florian; Konrad, Carina; Lodrini, Marco; Deubzer, Hedwig E; von Deimling, Andreas; Kulozik, Andreas E; Pfister, Stefan M; Witt, Olaf; Milde, Till (BioMed Central, 2015)
      Introduction: Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Four subgroups with distinct genetic, epigenetic and clinical characteristics have been identified. Survival remains particularly ...
    • Targeting Human Transmission Biology for Malaria Elimination 

      Nilsson, Sandra K.; Childs, Lauren M.; Buckee, Caroline; Marti, Matthias (Public Library of Science, 2015)
      Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by many endemic countries to eliminate malaria marks a shift away from programs aimed at controlling ...
    • Targeting Imperfect Vaccines against Drug-Resistance Determinants: A Strategy for Countering the Rise of Drug Resistance 

      Joice, Regina; Lipsitch, Marc (Public Library of Science, 2013)
      The growing prevalence of antimicrobial resistance in major pathogens is outpacing discovery of new antimicrobial classes. Vaccines mitigate the effect of antimicrobial resistance by reducing the need for treatment, but ...
    • Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia 

      Fenouille, Nina; Bassil, Christopher; Ben-Sahra, Issam; Benajiba, Lina; Alexe, Gabriela; Ramos, Azucena; Pikman, Yana; Conway, Amy; Burgess, Michael; Li, Qing; Luciano, Frédéric; Auberger, Patrick; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Zhang, Yi; Perkins, Archibald; Shannon, Kevin; Hemann, Michael; Puissant, Alexandre (American Society of Hematology, 2017)
      Abnormal expression of the transcription factor EVI1 through chromosome 3q26 rearrangements has been implicated in the development of one of the most therapeutically challenging high-risk subtypes of acute myeloid leukemia ...
    • Task shifting in health care: the risks of integrated medicine in India 

      Balsari, Satchit; Simon, Greg; Nair, Rajalakshmi; Saunik, Sujata; Phadke, Mrudula (Elsevier BV, 2017-10)
    • tat Exon 1 Exhibits Functional Diversity during HIV-1 Subtype C Primary Infection 

      Rossenkhan, R.; MacLeod, Iain James; Sebunya, T. K.; Castro-Nallar, E.; McLane, Mary Frances; Musonda, Rosemary Mubanga; Gashe, B. A.; Novitsky, Vladimir A.; Essex, Myron Elmer (American Society for Microbiology, 2013)
      Human immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription and is involved in the control of virus replication. However, associations between HIV-1 Tat diversity and functional effects during ...
    • Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy 

      Kopeikina, Katherine J.; Wegmann, Susanne; Pitstick, Rose; Carlson, George A.; Bacskai, Brian J.; Betensky, Rebecca A.; Hyman, Bradley T.; Spires-Jones, Tara L. (Public Library of Science, 2013)
      Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer’s disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is ...
    • Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses 

      Rudinskiy, Nikita; Hawkes, Jonathan M; Wegmann, Susanne; Kuchibhotla, Kishore V; Muzikansky, Alona; Betensky, Rebecca A; Spires-Jones, Tara L; Hyman, Bradley T (BioMed Central, 2014)
      Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle load correlates ...