Now showing items 6348-6362 of 6362

    • XBP1 Governs Late Events in Plasma Cell Differentiation and Is not Required for Antigen-Specific Memory B Cell Development 

      McHeyzer-Williams, Louise J.; Kowal, Czeslawa; Lee, Ann-Hwee; Volpe, Bruce T.; Diamond, Betty; McHeyzer-Williams, Michael G.; Todd, Derrick James; Glimcher, Laurie Hollis (Rockefeller University Press, 2009)
      The unfolded protein response (UPR) is a stress response pathway that is driven by the increased load of unfolded proteins in the endoplasmic reticulum of highly secretory cells such as plasma cells (PCs). X box binding ...
    • XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway 

      Chen, Xi; Iliopoulos, Dimitrios; Zhang, Qing; Tang, Qianzi; Greenblatt, Matthew B.; Hatziapostolou, Maria; Lim, Elgene; Tam, Wai Leong; Ni, Min; Chen, Yiwen; Mai, Junhua; Shen, Haifa; Hu, Dorothy Z.; Adoro, Stanley; Hu, Bella; Song, Minkyung; Tan, Chen; Landis, Melissa D.; Ferrari, Mauro; Shin, Sandra J.; Brown, Myles; Chang, Jenny C.; Liu, X. Shirley; Glimcher, Laurie H. (2014)
      Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization1. One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress ...
    • XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease 

      Cameron, Trevor L.; Bell, Katrina M.; Gresshoff, Irma L.; Sampurno, Lisa; Mullan, Lorna; Ermann, Joerg; Glimcher, Laurie H.; Boot-Handford, Raymond P.; Bateman, John F. (Public Library of Science, 2015)
      Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying ...
    • Y Chromosome Haplogroups and Prostate Cancer in Populations of European and Ashkenazi Jewish Ancestry 

      Wang, Zhaoming; Parikh, Hemang; Jia, Jinping; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laurie; Ghosh, Arpita; Thun, Michael J.; Gapstur, Susan M.; Virtamo, Jarmo; Albanes, Demetrius; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Offit, Kenneth; Dutra-Clarke, Ana; Kirchhoff, Tomas; Alavanja, Michael; Freeman, Laura B.; Koutros, Stella; Hoover, Robert; Berndt, Sonja I.; Hayes, Richard B.; Agalliu, Ilir; Burk, Robert D.; Wacholder, Sholom; Thomas, Gilles; Amundadottir, Laufey; Myers, Timothy; Giovannucci, Edward L.; Ma, Jing; Stampfer, Meir; Gaziano, John Michael; Hunter, David J.; Diver, W. Ryan (Springer-Verlag, 2012)
      Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ...
    • Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations 

      Badro, Danielle A.; Douaihy, Bouchra; Haber, Marc; Youhanna, Sonia C.; Salloum, Angélique; Ghassibe-Sabbagh, Michella; Johnsrud, Brian; Khazen, Georges; Matisoo-Smith, Elizabeth; Soria-Hernanz, David F.; Wells, R. Spencer; Tyler-Smith, Chris; Platt, Daniel E.; Zalloua, Pierre A. (Public Library of Science, 2013)
      The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ...
    • Years of Able Life in Older Persons—The Role of Cardiovascular Imaging and Biomarkers: The Cardiovascular Health Study 

      Alshawabkeh, Laith I.; Yee, Laura M.; Gardin, Julius M.; Gottdiener, John S.; Odden, Michelle C.; Bartz, Traci M.; Arnold, Alice M.; Mukamal, Kenneth J.; Wallace, Robert B. (Blackwell Publishing Ltd, 2015)
      Background: As the U.S. population grows older, there is greater need to examine physical independence. Previous studies have assessed risk factors in relation to either disability or mortality, but an outcome that combines ...
    • You Name It – How Memory and Delay Govern First Name Dynamics 

      Kessler, David A.; Maruvka, Yosef E.; Ouren, Jøergen; Shnerb, Nadav M. (Public Library of Science, 2012)
      The adoption and abandonment of first names through time is a fascinating phenomenon that may shed light on social dynamics and the forces that determine cultural taste in general. Here we show that baby name dynamics is ...
    • ZBTB20 is required for anterior pituitary development and lactotrope specification 

      Cao, Dongmei; Ma, Xianhua; Cai, Jiao; Luan, Jing; Liu, An-Jun; Yang, Rui; Cao, Yi; Zhu, Xiaotong; Zhang, Hai; Chen, Yu-Xia; Shi, Yuguang; Shi, Guang-Xia; Zou, Dajin; Cao, Xuetao; Grusby, Michael J.; Xie, Zhifang; Zhang, Weiping J. (Nature Publishing Group, 2016)
      The anterior pituitary harbours five distinct hormone-producing cell types, and their cellular differentiation is a highly regulated and coordinated process. Here we show that ZBTB20 is essential for anterior pituitary ...
    • Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival 

      Jones, Matthew R.; Blahna, Matthew T.; Kozlowski, Elyse; Matsuura, Kori Y.; Ferrari, Joseph D.; Morris, Samantha A; Powers, John T; Daley, George Quentin; Quinton, Lee J.; Mizgerd, Joseph P. (Public Library of Science, 2012)
      The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can ...
    • The Zelnorm Epidemiologic Study (ZEST): A Cohort Study Evaluating Incidence of Abdominal and Pelvic Surgery Related to Tegaserod Treatment 

      Seeger, John; Quinn, Sherry; Earnest, David L; Lembo, Anthony J.; Kuo, Braden; Rivero, Elena; Walker, Alexander M. (BioMed Central, 2012)
      Background: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of ...
    • Zinc Supplement Use and Risk of Prostate Cancer 

      Leitzmann, M. F.; Stampfer, Meir; Wu, K.; Colditz, G. A.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Giovannucci, E. L. (Oxford University Press, 2003)
      The high concentration of zinc in the prostate suggests that zinc may play a role in prostate health. We examined the association between supplemental zinc intake and prostate cancer risk among 46974 U.S. men participating ...
    • α-Methylacyl-CoA racemase expression and lethal prostate cancer in the Physicians’ Health Study and Health Professionals Follow-up Study 

      Barry, Marc; Dhillon, Preet K.; Stampfer, Meir; Perner, Sven; Ma, Jing; Giovannucci, Edward; Kurth, Tobias; Mucci, Lorelei A.; Rubin, Mark A. (Wiley, 2012)
      BACKGROUND a-Methylacyl-CoA racemase (AMACR) is an enzyme that serves as a diagnostic biomarker of prostate cancer in clinical practice. Recent studies suggest that low AMACR expression is associated with biochemical ...
    • β2‐Microglobulin, Cystatin C, and Creatinine and Risk of Symptomatic Peripheral Artery Disease 

      Joosten, Michel M.; Pai, Jennifer K.; Bertoia, Monica L.; Gansevoort, Ron T.; Bakker, Stephan J. L.; Cooke, John P.; Rimm, Eric B.; Mukamal, Kenneth J. (Blackwell Publishing Ltd, 2014)
      Background: β2‐Microglobulin and cystatin C may have advantages over creatinine in assessing risk associated with kidney function. We therefore investigated whether emerging filtration markers, β2‐microglobulin and cystatin ...
    • γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice 

      Mathews, Joel A.; Kasahara, David I.; Ribeiro, Luiza; Wurmbrand, Allison P.; Ninin, Fernanda M. C.; Shore, Stephanie A. (Public Library of Science, 2015)
      We examined the role of γδ T cells in the induction of alternatively activated M2 macrophages and the resolution of inflammation after ozone exposure. Wildtype (WT) mice and mice deficient in γδ T cells (TCRδ-/- mice) were ...
    • γδ T Cells Are Required for Pulmonary IL-17A Expression after Ozone Exposure in Mice: Role of TNFα 

      Mathews, Joel A.; Williams, Alison S.; Brand, Jeffrey D.; Wurmbrand, Allison P.; Chen, Lucas; Ninin, Fernanda MC.; Si, Huiqing; Kasahara, David I.; Shore, Stephanie A. (Public Library of Science, 2014)
      Ozone is an air pollutant that causes pulmonary symptoms. In mice, ozone exposure causes pulmonary injury and increases bronchoalveolar lavage macrophages and neutrophils. We have shown that IL-17A is important in the ...