Now showing items 6355-6362 of 6362

    • ZBTB20 is required for anterior pituitary development and lactotrope specification 

      Cao, Dongmei; Ma, Xianhua; Cai, Jiao; Luan, Jing; Liu, An-Jun; Yang, Rui; Cao, Yi; Zhu, Xiaotong; Zhang, Hai; Chen, Yu-Xia; Shi, Yuguang; Shi, Guang-Xia; Zou, Dajin; Cao, Xuetao; Grusby, Michael J.; Xie, Zhifang; Zhang, Weiping J. (Nature Publishing Group, 2016)
      The anterior pituitary harbours five distinct hormone-producing cell types, and their cellular differentiation is a highly regulated and coordinated process. Here we show that ZBTB20 is essential for anterior pituitary ...
    • Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival 

      Jones, Matthew R.; Blahna, Matthew T.; Kozlowski, Elyse; Matsuura, Kori Y.; Ferrari, Joseph D.; Morris, Samantha A; Powers, John T; Daley, George Quentin; Quinton, Lee J.; Mizgerd, Joseph P. (Public Library of Science, 2012)
      The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can ...
    • The Zelnorm Epidemiologic Study (ZEST): A Cohort Study Evaluating Incidence of Abdominal and Pelvic Surgery Related to Tegaserod Treatment 

      Seeger, John; Quinn, Sherry; Earnest, David L; Lembo, Anthony J.; Kuo, Braden; Rivero, Elena; Walker, Alexander M. (BioMed Central, 2012)
      Background: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of ...
    • Zinc Supplement Use and Risk of Prostate Cancer 

      Leitzmann, M. F.; Stampfer, Meir; Wu, K.; Colditz, G. A.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Giovannucci, E. L. (Oxford University Press, 2003)
      The high concentration of zinc in the prostate suggests that zinc may play a role in prostate health. We examined the association between supplemental zinc intake and prostate cancer risk among 46974 U.S. men participating ...
    • α-Methylacyl-CoA racemase expression and lethal prostate cancer in the Physicians’ Health Study and Health Professionals Follow-up Study 

      Barry, Marc; Dhillon, Preet K.; Stampfer, Meir; Perner, Sven; Ma, Jing; Giovannucci, Edward; Kurth, Tobias; Mucci, Lorelei A.; Rubin, Mark A. (Wiley, 2012)
      BACKGROUND a-Methylacyl-CoA racemase (AMACR) is an enzyme that serves as a diagnostic biomarker of prostate cancer in clinical practice. Recent studies suggest that low AMACR expression is associated with biochemical ...
    • β2‐Microglobulin, Cystatin C, and Creatinine and Risk of Symptomatic Peripheral Artery Disease 

      Joosten, Michel M.; Pai, Jennifer K.; Bertoia, Monica L.; Gansevoort, Ron T.; Bakker, Stephan J. L.; Cooke, John P.; Rimm, Eric B.; Mukamal, Kenneth J. (Blackwell Publishing Ltd, 2014)
      Background: β2‐Microglobulin and cystatin C may have advantages over creatinine in assessing risk associated with kidney function. We therefore investigated whether emerging filtration markers, β2‐microglobulin and cystatin ...
    • γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice 

      Mathews, Joel A.; Kasahara, David I.; Ribeiro, Luiza; Wurmbrand, Allison P.; Ninin, Fernanda M. C.; Shore, Stephanie A. (Public Library of Science, 2015)
      We examined the role of γδ T cells in the induction of alternatively activated M2 macrophages and the resolution of inflammation after ozone exposure. Wildtype (WT) mice and mice deficient in γδ T cells (TCRδ-/- mice) were ...
    • γδ T Cells Are Required for Pulmonary IL-17A Expression after Ozone Exposure in Mice: Role of TNFα 

      Mathews, Joel A.; Williams, Alison S.; Brand, Jeffrey D.; Wurmbrand, Allison P.; Chen, Lucas; Ninin, Fernanda MC.; Si, Huiqing; Kasahara, David I.; Shore, Stephanie A. (Public Library of Science, 2014)
      Ozone is an air pollutant that causes pulmonary symptoms. In mice, ozone exposure causes pulmonary injury and increases bronchoalveolar lavage macrophages and neutrophils. We have shown that IL-17A is important in the ...