Browsing SPH Scholarly Articles by Keyword "Dementia"
Now showing items 1-6 of 6
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Body Mass Index and Decline of Cognitive Function
(Public Library of Science, 2016)Background: The association between body mass index (BMI) and cognitive function is a public health issue. This study investigated the relationship between obesity and cognitive impairment which was assessed by the Korean ... -
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
(Public Library of Science, 2014)Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify ... -
Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study
(Public Library of Science, 2016)Background: Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive ... -
Prevalence and Characteristics of Interventional Trials Conducted Exclusively in Elderly Persons: A Cross-Sectional Analysis of Registered Clinical Trials
(Public Library of Science, 2016)Background: Elderly patients represent the greatest consumers of healthcare per capita but have historically been underrepresented in clinical trials. It is unknown how many trials are designed to focus exclusively on ... -
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease
(Public Library of Science, 2016)We performed an exome-wide association analysis in 1393 late-onset Alzheimer’s disease (LOAD) cases and 8141 controls from the CHARGE consortium. We found that a rare variant (P155L) in TM2D3 was enriched in Icelanders ... -
Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells
(Public Library of Science, 2016)The testing of candidate drugs to slow progression of Alzheimer’s disease (AD) requires clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the AD brain may be greatly facilitated by ...