Abnormal Hair Development and Apparent Follicular Transformation to Mammary Gland in the Absence of Hedgehog Signaling

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Abnormal Hair Development and Apparent Follicular Transformation to Mammary Gland in the Absence of Hedgehog Signaling

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dc.contributor.author Gritli-Linde, Amel
dc.contributor.author Hallberg, Kristina
dc.contributor.author Harfe, Brian D.
dc.contributor.author Reyahi, Azadeh
dc.contributor.author Kannius-Janson, Marie
dc.contributor.author Nilsson, Jeanette
dc.contributor.author Cobourne, Martyn T.
dc.contributor.author Sharpe, Paul T.
dc.contributor.author Linde, Anders
dc.contributor.author McMahon, Andrew P.
dc.date.accessioned 2010-10-01T18:40:21Z
dc.date.issued 2007
dc.identifier.citation Gritli-Linde, Amel, Kristina Hallberg, Brian D. Harfe, Azadeh Reyahi, Marie Kannius-Janson, Jeanette Nilsson, Martyn T. Cobourne, Paul T. Sharpe, Andrew P. McMahon, and Anders Linde. 2007. Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Developmental Cell 12(1): 99-112. en_US
dc.identifier.issn 1534-5807 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4455261
dc.description.abstract Summary: We show that removing the Shh signal tranducer Smoothened from skin epithelium secondarily results in excess Shh levels in the mesenchyme. Moreover, the phenotypes we observe reflect decreased epithelial Shh signaling, yet increased mesenchymal Shh signaling. For example, the latter contributes to exuberant hair follicle (HF) induction, while the former depletes the resulting follicular stem cell niches. This disruption of the niche apparently also allows the remaining stem cells to initiate hair formation at inappropriate times. Thus, the temporal structure of the hair cycle may depend on the physical structure of the niche. Finally, we find that the ablation of epithelial Shh signaling results in unexpected transformations: the follicular outer root sheath takes on an epidermal character, and certain HFs disappear altogether, having adopted a strikingly mammary gland-like fate. Overall, our study uncovers a multifaceted function for Shh in sculpting and maintaining the integrity and identity of the developing HF. en_US
dc.description.sponsorship Stem Cell and Regenerative Biology en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.isversionof doi:10.1016/j.devcel.2006.12.006 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885956/pdf/ en_US
dash.license LAA
dc.title Abnormal Hair Development and Apparent Follicular Transformation to Mammary Gland in the Absence of Hedgehog Signaling en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Developmental Cell en_US
dash.depositing.author McMahon, Andrew P.
dc.date.available 2010-10-01T18:40:21Z

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  • FAS Scholarly Articles [6868]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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