Charge as a Selection Criterion for Translocation through the Nuclear Pore Complex

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Charge as a Selection Criterion for Translocation through the Nuclear Pore Complex

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Title: Charge as a Selection Criterion for Translocation through the Nuclear Pore Complex
Author: Ribbeck, Katharina; Gilson, Michael; Colwell, Lucy Jane; Brenner, Michael P.

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Citation: Colwell, Lucy J., Brenner, Michael P., Ribbeck, Katharina, and Michael Gilson. 2010. Charge as a Selection Criterion for Translocation through the Nuclear Pore Complex. PLoS Computational Biology 6(4): e1000747.
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Abstract: Nuclear pore complexes (NPCs) are highly selective filters that control the exchange of material between nucleus and cytoplasm. The principles that govern selective filtering by NPCs are not fully understood. Previous studies find that cellular proteins capable of fast translocation through NPCs (transport receptors) are characterized by a high proportion of hydrophobic surface regions. Our analysis finds that transport receptors and their complexes are also highly negatively charged. Moreover, NPC components that constitute the permeability barrier are positively charged. We estimate that electrostatic interactions between a transport receptor and the NPC result in an energy gain of several kBT, which would enable significantly increased translocation rates of transport receptors relative to other cellular proteins. We suggest that negative charge is an essential criterion for selective passage through the NPC.
Published Version: doi:10.1371/journal.pcbi.1000747
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858669/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4459220

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  • FAS Scholarly Articles [7588]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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