ChemBank: A Small-Molecule Screening and Cheminformatics Resource Database

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ChemBank: A Small-Molecule Screening and Cheminformatics Resource Database

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Title: ChemBank: A Small-Molecule Screening and Cheminformatics Resource Database
Author: Seiler, Kathleen Petri; George, Gregory A.; Happ, Mary Pat; Bodycombe, Nicole E.; Carrinski, Hyman A.; Norton, Stephanie; Brudz, Steve; Serrano, Martin; Ferraiolo, Paul; Tolliday, Nicola J.; Clemons, Paul A.; Sullivan, John P.; Muhlich, Jeremy; Schreiber, Stuart L.

Note: Order does not necessarily reflect citation order of authors.

Citation: Seiler, Kathleen Petri, Gregory A. George, Mary Pat Happ, Nicole E. Bodycombe, Hyman A. Carrinski, Stephanie Norton, Steve Brudz, et al. 2008. ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Research 36(Supp. 1, Database issue): D351-D359.
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Abstract: ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector.
Published Version: doi:10.1093/nar/gkm843
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238881/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4459224

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  • FAS Scholarly Articles [7374]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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