Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

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Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

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Title: Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
Author: Uchida, Takuya; Rodriquez, Manuela; Schreiber, Stuart L.

Note: Order does not necessarily reflect citation order of authors.

Citation: Uchida, Takuya, Manuela Rodriquez, and Stuart L. Schreiber. 2009. Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy. Organic Letters 11(7): 1559-1562.
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Abstract: Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.
Published Version: http://dx.doi.org/10.1021/ol900173t
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661762/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4460795

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  • FAS Scholarly Articles [6464]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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