A sex-ratio Meiotic Drive System in Drosophila simulans. II: An X-linked Distorter

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A sex-ratio Meiotic Drive System in Drosophila simulans. II: An X-linked Distorter

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Title: A sex-ratio Meiotic Drive System in Drosophila simulans. II: An X-linked Distorter
Author: Tao, Yun; Kingan, Sarah B; Ke, Yeyan; Xiao, Hailian; Barbash, Daniel; Araripe, Luciana Ordunha; Hartl, Daniel L.

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Citation: Tao, Yun, Luciana Araripe, Sarah B. Kingan, Yeyan Ke, Hailian Xiao, and Daniel L. Hartl. 2007. A meiotic drive system in Drosophila simulans. II: An X-linked distorter. PLoS Biology 5(11): e293.
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Abstract: The evolution of heteromorphic sex chromosomes creates a genetic condition favoring the invasion of sex-ratio meiotic drive elements, resulting in the biased transmission of one sex chromosome over the other, in violation of Mendel's first law. The molecular mechanisms of sex-ratio meiotic drive may therefore help us to understand the evolutionary forces shaping the meiotic behavior of the sex chromosomes. Here we characterize a sex-ratio distorter on the X chromosome (Dox) in Drosophila simulans by genetic and molecular means. Intriguingly, Dox has very limited coding capacity. It evolved from another X-linked gene, which also evolved de nova. Through retrotransposition, Dox also gave rise to an autosomal suppressor, not much yang (Nmy). An RNA interference mechanism seems to be involved in the suppression of the Dox distorter by the Nmy suppressor. Double mutant males of the genotype dox; nmy are normal for both sex-ratio and spermatogenesis. We postulate that recurrent bouts of sex-ratio meiotic drive and its subsequent suppression might underlie several common features observed in the heterogametic sex, including meiotic sex chromosome inactivation and achiasmy.
Published Version: doi:10.1371/journal.pbio.0050293
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062476/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4460832

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  • FAS Scholarly Articles [6464]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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