Large-Scale Assessment of the Effect of Popularity on the Reliability of Research

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Large-Scale Assessment of the Effect of Popularity on the Reliability of Research

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Title: Large-Scale Assessment of the Effect of Popularity on the Reliability of Research
Author: Hoffmann, Robert; Pfeiffer, Thomas

Note: Order does not necessarily reflect citation order of authors.

Citation: Pfeiffer, Thomas, and Robert Hoffmann. 2009. Large-scale assessment of the effect of popularity on the reliability of research. PLoS ONE 4:e5996.
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Abstract: Based on theoretical reasoning it has been suggested that the reliability of findings published in the scientific literature decreases with the popularity of a research field. Here we provide empirical support for this prediction. We evaluate published statements on protein interactions with data from high-throughput experiments. We find evidence for two distinctive effects. First, with increasing popularity of the interaction partners, individual statements in the literature become more erroneous. Second, the overall evidence on an interaction becomes increasingly distorted by multiple independent testing. We therefore argue that for increasing the reliability of research it is essential to assess the negative effects of popularity and develop approaches to diminish these effects.
Published Version: doi:10.1371/ journal.pone.0005996
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696594/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4513838

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  • FAS Scholarly Articles [6929]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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