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dc.contributor.authorPfeiffer, Thomas
dc.contributor.authorHoffmann, Robert
dc.date.accessioned2010-10-28T20:03:15Z
dc.date.issued2009
dc.identifier.citationPfeiffer, Thomas, and Robert Hoffmann. 2009. Large-scale assessment of the effect of popularity on the reliability of research. PLoS ONE 4:e5996.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4513838
dc.description.abstractBased on theoretical reasoning it has been suggested that the reliability of findings published in the scientific literature decreases with the popularity of a research field. Here we provide empirical support for this prediction. We evaluate published statements on protein interactions with data from high-throughput experiments. We find evidence for two distinctive effects. First, with increasing popularity of the interaction partners, individual statements in the literature become more erroneous. Second, the overall evidence on an interaction becomes increasingly distorted by multiple independent testing. We therefore argue that for increasing the reliability of research it is essential to assess the negative effects of popularity and develop approaches to diminish these effects.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/ journal.pone.0005996en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696594/pdf/en_US
dash.licenseLAA
dc.subjectscience policyen_US
dc.subjectcomputational biologyen_US
dc.subjectliterature analysisen_US
dc.subjectmathematicsen_US
dc.subjectstatisticsen_US
dc.titleLarge-Scale Assessment of the Effect of Popularity on the Reliability of Researchen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorPfeiffer, Thomas
dc.date.available2010-10-28T20:03:15Z
dc.identifier.doi10.1371/ journal.pone.0005996*
dash.contributor.affiliatedPfeiffer, Thomas


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