Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

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Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

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dc.contributor.author Samore, Matthew H.
dc.contributor.author Lipsitch, Marc
dc.date.accessioned 2010-11-12T20:02:08Z
dc.date.issued 2002
dc.identifier.citation Lipsitch, Marc, and Matthew H. Samore. 2002. Antimicrobial Use and Antimicrobial Resistance: A Population Perspective. Emerging Infectious Diseases 8(4): 347-354. en_US
dc.identifier.issn 1080-6040 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553777
dc.description.abstract The need to stem the growing problem of antimicrobial resistance has prompted multiple, sometimes conflicting, calls for changes in the use of antimicrobial agents. One source of disagreement concerns the major mechanisms by which antibiotics select resistant strains. For infections like tuberculosis, in which resistance can emerge in treated hosts through mutation, prevention of antimicrobial resistance in individual hosts is a primary method of preventing the spread of resistant organisms in the community. By contrast, for many other important resistant pathogens, such as penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecium resistance is mediated by the acquisition of genes or gene fragments by horizontal transfer; resistance in the treated host is a relatively rare event. For these organisms, indirect, population-level mechanisms of selection account for the increase in the prevalence of resistance. These mechanisms can operate even when treatment has a modest, or even negative, effect on an individual host’s colonization with resistant organisms. en_US
dc.language.iso en_US en_US
dc.publisher Centers for Disease Control and Prevention en_US
dc.relation.isversionof doi:10.3201/eid0804.010312 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730242/pdf/ en_US
dash.license LAA
dc.title Antimicrobial Use and Antimicrobial Resistance: A Population Perspective en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Emerging Infectious Diseases en_US
dash.depositing.author Lipsitch, Marc
dc.date.available 2010-11-12T20:02:08Z
dash.affiliation.other SPH^Epidemiology en_US

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