Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

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Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

dc.contributor.author	Samore, Matthew H.
dc.contributor.author	Lipsitch, Marc
dc.date.accessioned	2010-11-12T20:02:08Z
dc.date.issued	2002
dc.identifier.citation	Lipsitch, Marc, and Matthew H. Samore. 2002. Antimicrobial Use and Antimicrobial Resistance: A Population Perspective. Emerging Infectious Diseases 8(4): 347-354.	en_US
dc.identifier.issn	1080-6040	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553777
dc.description.abstract	The need to stem the growing problem of antimicrobial resistance has prompted multiple, sometimes conflicting, calls for changes in the use of antimicrobial agents. One source of disagreement concerns the major mechanisms by which antibiotics select resistant strains. For infections like tuberculosis, in which resistance can emerge in treated hosts through mutation, prevention of antimicrobial resistance in individual hosts is a primary method of preventing the spread of resistant organisms in the community. By contrast, for many other important resistant pathogens, such as penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecium resistance is mediated by the acquisition of genes or gene fragments by horizontal transfer; resistance in the treated host is a relatively rare event. For these organisms, indirect, population-level mechanisms of selection account for the increase in the prevalence of resistance. These mechanisms can operate even when treatment has a modest, or even negative, effect on an individual host’s colonization with resistant organisms.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Centers for Disease Control and Prevention	en_US
dc.relation.isversionof	doi:10.3201/eid0804.010312	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730242/pdf/	en_US
dash.license	LAA
dc.title	Antimicrobial Use and Antimicrobial Resistance: A Population Perspective	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Emerging Infectious Diseases	en_US
dash.depositing.author	Lipsitch, Marc
dc.date.available	2010-11-12T20:02:08Z
dash.affiliation.other	SPH^Epidemiology	en_US