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dc.contributor.author	Gokhale, Chaitanya S.
dc.contributor.author	Iwasa, Yoh
dc.contributor.author	Nowak, Martin A.
dc.contributor.author	Traulsen, Arne
dc.date.accessioned	2010-11-15T20:34:13Z
dc.date.issued	2009
dc.identifier.citation	Gokhale Chaitanya S., Yoh Iwasa, Martin A. Nowak, and Arne Traulsen. 2009. The pace of evolution across fitness valleys. Journal of Theoretical Biology 259(3): 613-620.	en_US
dc.identifier.issn	0022-5193	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4554750
dc.description.abstract	How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a population has evolved from one fitness peak to another one with a higher fitness. The order of mutations can either be fixed or random. If the order of mutations is fixed, then the population follows a metaphorical ridge, a single path. If the order of mutations is arbitrary, then there are many ways to evolve to the higher fitness state. We address the time required for fixation in such scenarios and study how it is affected by the order of mutations, the population size, the fitness values and the mutation rate.	en_US
dc.description.sponsorship	Mathematics	en_US
dc.description.sponsorship	Organismic and Evolutionary Biology	en_US
dc.language.iso	en_US	en_US
dc.publisher	Elsevier	en_US
dc.relation.isversionof	doi:10.1016/j.jtbi.2009.04.011	en_US
dc.relation.hasversion	http://www.ped.fas.harvard.edu/people/faculty/all_publications.html#2009	en_US
dash.license	META_ONLY
dc.subject	finite populations	en_US
dc.subject	stochastic tunneling	en_US
dc.subject	evolutionary speed	en_US
dc.title	The Pace of Evolution Across Fitness Valleys	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Journal of Theoretical Biology	en_US
dash.depositing.author	Nowak, Martin A.
dash.embargo.until	10000-01-01

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  Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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