The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation
| Title: | The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation |
| Author: | Lassar, Andrew B. |
| Citation: | Lassar, Andrew B. 2009. The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation. The Journal of Cell Biology 187(7): 941-943. |
| Full Text & Related Files: |
2806286.pdf (1.290Mb; PDF) 
|
| Abstract: | In this issue, Gillespie et al. (Gillespie et al. 2009. J. Cell Biol. doi:10.1083/jcb.200907037) demonstrate that the mitogen-activated protein kinase isoform p38-γ plays a crucial role in blocking the premature differentiation of satellite cells, a skeletal muscle stem cell population. p38-γ puts the brakes on skeletal muscle differentiation by promoting the association of the transcription factor MyoD with the histone methyltransferase, KMT1A, which act together in a complex to repress the premature expression of the gene encoding the myogenic transcription factor Myogenin. |
| Published Version: | doi:10.1083/jcb.200911123 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806286/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621009 |
This item appears in the following Collection(s)
-
HMS Scholarly Articles [4046]
Contact administrator regarding this item (to report mistakes or request changes)
