The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation
View/ Open
Author
Published Version
https://doi.org/10.1083/jcb.200911123Metadata
Show full item recordCitation
Lassar, Andrew B. 2009. The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation. The Journal of Cell Biology 187(7): 941-943.Abstract
In this issue, Gillespie et al. (Gillespie et al. 2009. J. Cell Biol. doi:10.1083/jcb.200907037) demonstrate that the mitogen-activated protein kinase isoform p38-γ plays a crucial role in blocking the premature differentiation of satellite cells, a skeletal muscle stem cell population. p38-γ puts the brakes on skeletal muscle differentiation by promoting the association of the transcription factor MyoD with the histone methyltransferase, KMT1A, which act together in a complex to repress the premature expression of the gene encoding the myogenic transcription factor Myogenin.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806286/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621009
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)