The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation

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The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation

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Title: The p38 MAPK Family, a Pushmi-pullyu of Skeletal Muscle Differentiation
Author: Lassar, Andrew B.
Citation: Lassar, Andrew B. 2009. The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation. The Journal of Cell Biology 187(7): 941-943.
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Abstract: In this issue, Gillespie et al. (Gillespie et al. 2009. J. Cell Biol. doi:10.1083/jcb.200907037) demonstrate that the mitogen-activated protein kinase isoform p38-γ plays a crucial role in blocking the premature differentiation of satellite cells, a skeletal muscle stem cell population. p38-γ puts the brakes on skeletal muscle differentiation by promoting the association of the transcription factor MyoD with the histone methyltransferase, KMT1A, which act together in a complex to repress the premature expression of the gene encoding the myogenic transcription factor Myogenin.
Published Version: doi:10.1083/jcb.200911123
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806286/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621009

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