Long-term Monitoring of Post-stroke Plasticity after Transient Cerebral Ischemia in Mice Using in vivo and ex vivo Diffusion Tensor MRI

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Long-term Monitoring of Post-stroke Plasticity after Transient Cerebral Ischemia in Mice Using in vivo and ex vivo Diffusion Tensor MRI

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Title: Long-term Monitoring of Post-stroke Plasticity after Transient Cerebral Ischemia in Mice Using in vivo and ex vivo Diffusion Tensor MRI
Author: Granziera, C; D’Arceuil, H; Magistretti, P.J; de Crespigny, A.J; Zai, Laila; Sorensen, Alma Gregory

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Citation: Granziera, C., H. D’Arceuil, L. Zai, P.J. Magistretti, A.G. Sorensen, and A.J. de Crespigny. 2007. Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI. The Open Neuroimaging Journal 1: 10-17.
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Abstract: We used a murine model of transient focal cerebral ischemia to study: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at days 4, 10, 15 and 21 after stroke 2) ex vivo distribution of a plasticity-related protein (GAP-43) and its relationship with the ex vivo DTI characteristics of the striato-thalamic pathway (21 days). All animals recovered motor function. In vivo ADC within the infarct was significantly increased after stroke. In the stroke group, GAP-43 expression and FA values were significantly higher in the ipsilateral (IL) striatum and contralateral (CL) hippocampus compared to the shams. DTI tractography showed fiber trajectories connecting the CL striatum to the stroke region, where increased GAP43 and FA were observed and fiber tracts from the CL striatum terminating in the IL hippocampus. Our data demonstrate that DTI changes parallel histological remodeling and recovery of function.
Published Version: doi:10.2174/1874440000701010010
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577937/pdf/
http://www.bentham.org/open/tonij/articles/V001/10TONIJ.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621599

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