The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

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The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

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Title: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Author: Firestein, Ron; Blander, Gil; Michan, Shaday; Oberdoerffer, Philipp; Luikenhuis, Sandra; de Cabo, Rafael; Guarente, Leonard P.; Ogino, Shuji; Campbell, Jennifer; Bhimavarapu, Anupama; Fuchs, Charles Stewart; Hahn, William C.; Sinclair, David Andrew

Note: Order does not necessarily reflect citation order of authors.

Citation: Firestein, Ron, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, Jennifer Campbell, Anupama Bhimavarapu, et al. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3(4): e2020.
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Abstract: Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of NAD+-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals. Here we show that CR induces a two-fold increase SIRT1 expression in the intestine of rodents and that ectopic induction of SIRT1 in a β-catenin-driven mouse model of colon cancer significantly reduces tumor formation, proliferation, and animal morbidity in the absence of CR. We show that SIRT1 deacetylates β-catenin and suppresses its ability to activate transcription and drive cell proliferation. Moreover, SIRT1 promotes cytoplasmic localization of the otherwise nuclear-localized oncogenic form of β-catenin. Consistent with this, a significant inverse correlation was found between the presence of nuclear SIRT1 and the oncogenic form of β−catenin in 81 human colon tumor specimens analyzed. Taken together, these observations show that SIRT1 suppresses intestinal tumor formation in vivo and raise the prospect that therapies targeting SIRT1 may be of clinical use in β−catenin-driven malignancies.
Published Version: doi:10.1371/journal.pone.0002020
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289879/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621701

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