The Why and How of DNA Unlinking

The Why and How of DNA Unlinking

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The Why and How of DNA Unlinking

dc.contributor.author	Liu, Zhirong
dc.contributor.author	Chan, Hue Sun
dc.contributor.author	Zechiedrich, Lynn
dc.contributor.author	Deibler, Richard Wendel
dc.date.accessioned	2010-12-09T20:16:24Z
dc.date.issued	2009
dc.identifier.citation	Liu, Zhirong, Richard W. Deibler, Hue Sun Chan, and Lynn Zechiedrich. 2009. The why and how of DNA unlinking. Nucleic Acids Research 37(3): 661-671.	en_US
dc.identifier.issn	0305-1048	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621863
dc.description.abstract	The nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control of gene transcription, faithful DNA replication and segregation, maintenance of the genome and cellular differentiation are subject to the conformational and topological properties of DNA in addition to the regulation imparted by the sequence itself. How do these DNA features manifest such striking effects and how does the cell regulate them? In this review, we describe how misregulation of DNA topology can lead to cellular dysfunction. We then address how cells prevent these topological problems. We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Oxford University Press	en_US
dc.relation.isversionof	doi:10.1093/nar/gkp041	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647305/pdf/	en_US
dash.license	LAA
dc.title	The Why and How of DNA Unlinking	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Nucleic Acids Research	en_US
dash.depositing.author	Deibler, Richard Wendel
dc.date.available	2010-12-09T20:16:24Z
dash.affiliation.other	HMS^Systems Biology	en_US