The Why and How of DNA Unlinking

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The Why and How of DNA Unlinking

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dc.contributor.author Liu, Zhirong
dc.contributor.author Chan, Hue Sun
dc.contributor.author Zechiedrich, Lynn
dc.contributor.author Deibler, Richard Wendel
dc.date.accessioned 2010-12-09T20:16:24Z
dc.date.issued 2009
dc.identifier.citation Liu, Zhirong, Richard W. Deibler, Hue Sun Chan, and Lynn Zechiedrich. 2009. The why and how of DNA unlinking. Nucleic Acids Research 37(3): 661-671. en_US
dc.identifier.issn 0305-1048 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621863
dc.description.abstract The nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control of gene transcription, faithful DNA replication and segregation, maintenance of the genome and cellular differentiation are subject to the conformational and topological properties of DNA in addition to the regulation imparted by the sequence itself. How do these DNA features manifest such striking effects and how does the cell regulate them? In this review, we describe how misregulation of DNA topology can lead to cellular dysfunction. We then address how cells prevent these topological problems. We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi:10.1093/nar/gkp041 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647305/pdf/ en_US
dash.license LAA
dc.title The Why and How of DNA Unlinking en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Nucleic Acids Research en_US
dash.depositing.author Deibler, Richard Wendel
dc.date.available 2010-12-09T20:16:24Z
dash.affiliation.other HMS^Systems Biology en_US

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