The 2007 WHO Classification of Tumours of the Central Nervous System

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The 2007 WHO Classification of Tumours of the Central Nervous System

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dc.contributor.author Ohgaki, Hiroko
dc.contributor.author Wiestler, Otmar D.
dc.contributor.author Cavenee, Webster K.
dc.contributor.author Burger, Peter C.
dc.contributor.author Jouvet, Anne
dc.contributor.author Scheithauer, Bernd W.
dc.contributor.author Kleihues, Paul
dc.contributor.author Louis, David Neil
dc.date.accessioned 2010-12-21T15:54:34Z
dc.date.issued 2007
dc.identifier.citation Louis, David N., Hiroko Ohgaki, Otmar D. Wiestler, Webster K. Cavenee, Peter C. Burger, Anne Jouvet, Bernd W. Scheithauer, and Paul Kleihues. 2007. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathologica 114(2): 97-109. en_US
dc.identifier.issn 0001-6322 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4632527
dc.description.abstract The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a different age distribution, location, genetic profile or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO ‘Blue Book’, the classification is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the definition of brain tumours to the clinical oncology and cancer research communities world-wide. en_US
dc.language.iso en_US en_US
dc.publisher Springer-Verlag en_US
dc.relation.isversionof doi:10.1007/s00401-007-0243-4 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929165/pdf/ en_US
dash.license LAA
dc.title The 2007 WHO Classification of Tumours of the Central Nervous System en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Acta Neuropathologica en_US
dash.depositing.author Louis, David Neil
dc.date.available 2010-12-21T15:54:34Z
dash.affiliation.other HMS^Pathology en_US

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