Hepatitis C Virus Infection Protein Network
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Author
de Chassey, B
Navratil, V
Tafforeau, L
Hiet, M S
Aublin-Gex, A
Agaugué, S
Meiffren, G
Pradezynski, F
Faria, B F
Chantier, T
Le Breton, M
Pellet, J
Davoust, N
Mangeot, P E
Chaboud, A
Penin, F
Jacob, Y
Vidalain, P O
André, P
Rabourdin-Combe, C
Lotteau, V
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/msb.2008.66Metadata
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de Chassey, B., V. Navratil, L. Tafforeau, M. S. Hiet, A. Aublin-Gex, S. Agaugué, G. Meiffren, et al. 2008. Hepatitis C virus infection protein network. Molecular Systems Biology 4: 230.Abstract
A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600670/pdf/Terms of Use
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