Hepatitis C Virus Infection Protein Network

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Hepatitis C Virus Infection Protein Network

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dc.contributor.author de Chassey, B
dc.contributor.author Navratil, V
dc.contributor.author Tafforeau, L
dc.contributor.author Hiet, M S
dc.contributor.author Aublin-Gex, A
dc.contributor.author Agaugué, S
dc.contributor.author Meiffren, G
dc.contributor.author Pradezynski, F
dc.contributor.author Faria, B F
dc.contributor.author Chantier, T
dc.contributor.author Le Breton, M
dc.contributor.author Pellet, J
dc.contributor.author Davoust, N
dc.contributor.author Mangeot, P E
dc.contributor.author Chaboud, A
dc.contributor.author Penin, F
dc.contributor.author Jacob, Y
dc.contributor.author Vidalain, P O
dc.contributor.author Vidal, Marc
dc.contributor.author André, P
dc.contributor.author Rabourdin-Combe, C
dc.contributor.author Lotteau, V
dc.date.accessioned 2010-12-21T16:01:12Z
dc.date.issued 2008
dc.identifier.citation de Chassey, B., V. Navratil, L. Tafforeau, M. S. Hiet, A. Aublin-Gex, S. Agaugué, G. Meiffren, et al. 2008. Hepatitis C virus infection protein network. Molecular Systems Biology 4: 230. en_US
dc.identifier.issn 1744-4292 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4632528
dc.description.abstract A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/msb.2008.66 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600670/pdf/ en_US
dash.license LAA
dc.subject functional analysis en_US
dc.subject hepatitis C en_US
dc.subject interactome en_US
dc.subject virus–host cell en_US
dc.title Hepatitis C Virus Infection Protein Network en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Molecular Systems Biology en_US
dash.depositing.author Vidal, Marc
dc.date.available 2010-12-21T16:01:12Z
dash.affiliation.other HMS^Genetics en_US

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