Hepatitis C Virus Infection Protein Network

Hepatitis C Virus Infection Protein Network

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Hepatitis C Virus Infection Protein Network

dc.contributor.author	de Chassey, B
dc.contributor.author	Navratil, V
dc.contributor.author	Tafforeau, L
dc.contributor.author	Hiet, M S
dc.contributor.author	Aublin-Gex, A
dc.contributor.author	Agaugué, S
dc.contributor.author	Meiffren, G
dc.contributor.author	Pradezynski, F
dc.contributor.author	Faria, B F
dc.contributor.author	Chantier, T
dc.contributor.author	Le Breton, M
dc.contributor.author	Pellet, J
dc.contributor.author	Davoust, N
dc.contributor.author	Mangeot, P E
dc.contributor.author	Chaboud, A
dc.contributor.author	Penin, F
dc.contributor.author	Jacob, Y
dc.contributor.author	Vidalain, P O
dc.contributor.author	Vidal, Marc
dc.contributor.author	André, P
dc.contributor.author	Rabourdin-Combe, C
dc.contributor.author	Lotteau, V
dc.date.accessioned	2010-12-21T16:01:12Z
dc.date.issued	2008
dc.identifier.citation	de Chassey, B., V. Navratil, L. Tafforeau, M. S. Hiet, A. Aublin-Gex, S. Agaugué, G. Meiffren, et al. 2008. Hepatitis C virus infection protein network. Molecular Systems Biology 4: 230.	en_US
dc.identifier.issn	1744-4292	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4632528
dc.description.abstract	A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Nature Publishing Group	en_US
dc.relation.isversionof	doi:10.1038/msb.2008.66	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600670/pdf/	en_US
dash.license	LAA
dc.subject	functional analysis	en_US
dc.subject	hepatitis C	en_US
dc.subject	interactome	en_US
dc.subject	virus–host cell	en_US
dc.title	Hepatitis C Virus Infection Protein Network	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Molecular Systems Biology	en_US
dash.depositing.author	Vidal, Marc
dc.date.available	2010-12-21T16:01:12Z
dash.affiliation.other	HMS^Genetics	en_US