Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges

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Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges

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dc.contributor.author Mendelson, Karen
dc.contributor.author Schoen, Frederick J.
dc.date.accessioned 2010-12-22T15:29:10Z
dc.date.issued 2006
dc.identifier.citation Mendelson, Karen, and Frederick J. Schoen. 2006. Heart valve tissue engineering: concepts, approaches, progress, and challenges. Annals of Biomedical Engineering 34(12): 1799-1819. en_US
dc.identifier.issn 0090-6964 en_US
dc.identifier.issn 1573-9686 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4633201
dc.description.abstract Potential applications of tissue engineering in regenerative medicine range from structural tissues to organs with complex function. This review focuses on the engineering of heart valve tissue, a goal which involves a unique combination of biological, engineering, and technological hurdles. We emphasize basic concepts, approaches and methods, progress made, and remaining challenges. To provide a framework for understanding the enabling scientific principles, we first examine the elements and features of normal heart valve functional structure, biomechanics, development, maturation, remodeling, and response to injury. Following a discussion of the fundamental principles of tissue engineering applicable to heart valves, we examine three approaches to achieving the goal of an engineered tissue heart valve: (1) cell seeding of biodegradable synthetic scaffolds, (2) cell seeding of processed tissue scaffolds, and (3) in-vivo repopulation by circulating endogenous cells of implanted substrates without prior in-vitro cell seeding. Lastly, we analyze challenges to the field and suggest future directions for both preclinical and translational (clinical) studies that will be needed to address key regulatory issues for safety and efficacy of the application of tissue engineering and regenerative approaches to heart valves. Although modest progress has been made toward the goal of a clinically useful tissue engineered heart valve, further success and ultimate human benefit will be dependent upon advances in biodegradable polymers and other scaffolds, cellular manipulation, strategies for rebuilding the extracellular matrix, and techniques to characterize and potentially non-invasively assess the speed and quality of tissue healing and remodeling. en_US
dc.language.iso en_US en_US
dc.publisher Kluwer Academic Publishers-Plenum Publishers en_US
dc.relation.isversionof doi:10.1007/s10439-006-9163-z en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705506/pdf/ en_US
dash.license LAA
dc.subject heart valvle remodeling en_US
dc.subject engineered tissue heart valves en_US
dc.subject biodegradable scaffold en_US
dc.subject decellularized scaffold en_US
dc.subject engineered tissue heart valves en_US
dc.subject heart valve remodelling en_US
dc.subject circulating stem cells en_US
dc.title Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Annals of Biomedical Engineering en_US
dash.depositing.author Schoen, Frederick J.
dc.date.available 2010-12-22T15:29:10Z
dash.affiliation.other HMS^Health Sciences and Technology en_US
dash.affiliation.other HMS^Pathology en_US

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