Analysis and Application of European Genetic Substructure Using 300 K SNP Information

DSpace/Manakin Repository

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

Citable link to this page

. . . . . .

Title: Analysis and Application of European Genetic Substructure Using 300 K SNP Information
Author: Tian, Chao; Ransom, Michael; Lee, Annette; Villoslada, Pablo; Selmi, Carlo; Klareskog, Lars; Pulver, Ann E; Qi, Lihong; Gregersen, Peter K; Seldin, Michael F; Plenge, Robert M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Tian, Chao, Robert M. Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Selmi, Lars Klareskog, et al. 2008. Analysis and Application of European Genetic Substructure Using 300 K SNP Information. PLoS Genetics 4(1): e4.
Full Text & Related Files:
Abstract: European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry. A second PC further separated Italian, Spanish, and Greek individuals from those of Ashkenazi Jewish ancestry as well as distinguishing among northern European populations. In separate analyses of northern European participants other substructure relationships were discerned showing a west to east gradient. Application of this substructure information was critical in examining a real dataset in whole genome association (WGA) analyses for rheumatoid arthritis in European Americans to reduce false positive signals. In addition, two sets of European substructure ancestry informative markers (ESAIMs) were identified that provide substantial substructure information. The results provide further insight into European population genetic substructure and show that this information can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans.
Published Version: doi:10.1371/journal.pgen.0040004
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211544/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4633202

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters