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dc.contributor.authorBecerra, Lino Renan
dc.contributor.authorHarris, William Hamilton
dc.contributor.authorGrant, Margaret
dc.contributor.authorGeorge, Edward E.
dc.contributor.authorBoas, David A.
dc.contributor.authorBorsook, David
dc.date.accessioned2011-01-14T20:53:55Z
dc.date.issued2009
dc.identifier.citationBecerra, Lino, Will Harris, Margaret Grant, Edward George, David Boas, and David Borsook. 2009. Diffuse optical tomography activation in the somatosensory cortex: Specific activation by painful vs. non-painful thermal stimuli. PLoS ONE 4(11): e8016.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4662024
dc.description.abstractBackground: Pain is difficult to assess due to the subjective nature of self-reporting. The lack of objective measures of pain has hampered the development of new treatments as well as the evaluation of current ones. Functional MRI studies of pain have begun to delineate potential brain response signatures that could be used as objective read-outs of pain. Using Diffuse Optical Tomography (DOT), we have shown in the past a distinct DOT signal over the somatosensory cortex to a noxious heat stimulus that could be distinguished from the signal elicited by innocuous mechanical stimuli. Here we further our findings by studying the response to thermal innocuous and noxious stimuli. Methodology/Principal Findings: Innocuous and noxious thermal stimuli were applied to the skin of the face of the first division (ophthalmic) of the trigeminal nerve in healthy volunteers (N = 6). Stimuli temperatures were adjusted for each subject to evoke warm (equivalent to a 3/10) and painful hot (7/10) sensations in a verbal rating scale (0/10 = no/max pain). A set of 26 stimuli (5 sec each) was applied for each temperature with inter-stimulus intervals varied between 8 and 15 sec using a Peltier thermode. A DOT system was used to capture cortical responses on both sides of the head over the primary somatosensory cortical region (S1). For the innocuous stimuli, group results indicated mainly activation on the contralateral side with a weak ipsilateral response. For the noxious stimuli, bilateral activation was observed with comparable amplitudes on both sides. Furthermore, noxious stimuli produced a temporal biphasic response while innocuous stimuli produced a monophasic response. Conclusions/Significance: These results are in accordance with fMRI and our other DOT studies of innocuous mechanical and noxious heat stimuli. The data indicate the differentiation of DOT cortical responses for pain vs. innocuous stimuli that may be useful in assessing objectively acute pain.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0008016en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778627/pdf/en_US
dash.licenseLAA
dc.subjectneuroscienceen_US
dc.subjectradiology and medical imagingen_US
dc.subjectsensory systemsen_US
dc.subjectanesthesiology and pain managementen_US
dc.subjectbasic science of pain managementen_US
dc.subjecttechnology and monitoringen_US
dc.subjectneurological disordersen_US
dc.subjectpain managementen_US
dc.subjectpsychologyen_US
dc.titleDiffuse Optical Tomography Activation in the Somatosensory Cortex: Specific Activation by Painful vs. Non-Painful Thermal Stimulien_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorBoas, David A.
dc.date.available2011-01-14T20:53:55Z
dash.affiliation.otherHMS^Radiology-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dc.identifier.doi10.1371/journal.pone.0008016*
dash.contributor.affiliatedHarris, William
dash.contributor.affiliatedGeorge, Edward
dash.contributor.affiliatedBecerra, Lino
dash.contributor.affiliatedBorsook, David
dash.contributor.affiliatedBoas, David


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