GenePING: Secure, Scalable Management of Personal Genomic Data

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GenePING: Secure, Scalable Management of Personal Genomic Data

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dc.contributor.author Adida, Benjamin M
dc.contributor.author Kohane, Isaac Samuel
dc.date.accessioned 2011-02-07T16:40:03Z
dc.date.issued 2006
dc.identifier.citation Adida, Ben, and Isaac S Kohane. 2006. GenePING: secure, scalable management of personal genomic data. BMC Genomics 7: 93. en_US
dc.identifier.issn 1471-2164 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4706314
dc.description.abstract Background: Patient genomic data are rapidly becoming part of clinical decision making. Within a few years, full genome expression profiling and genotyping will be affordable enough to perform on every individual. The management of such sizeable, yet fine-grained, data in compliance with privacy laws and best practices presents significant security and scalability challenges. Results: We present the design and implementation of GenePING, an extension to the PING personal health record system that supports secure storage of large, genome-sized datasets, as well as efficient sharing and retrieval of individual datapoints (e.g. SNPs, rare mutations, gene expression levels). Even with full access to the raw GenePING storage, an attacker cannot discover any stored genomic datapoint on any single patient. Given a large-enough number of patient records, an attacker cannot discover which data corresponds to which patient, or even the size of a given patient's record. The computational overhead of GenePING's security features is a small constant, making the system usable, even in emergency care, on today's hardware. Conclusion: GenePING is the first personal health record management system to support the efficient and secure storage and sharing of large genomic datasets. GenePING is available online at http://ping.chip.org/genepinghtml/, licensed under the LGPL. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/1471-2164-7-93 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524750/pdf/ en_US
dash.license LAA
dc.title GenePING: Secure, Scalable Management of Personal Genomic Data en_US
dc.type Journal Article en_US
dc.description.version Proof en_US
dc.relation.journal BMC Genomics en_US
dash.depositing.author Kohane, Isaac Samuel
dc.date.available 2011-02-07T16:40:03Z
dash.affiliation.other HMS^Countway Library of Medicine en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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