Expression Dynamics of a Cellular Metabolic Network
| Title: | Expression Dynamics of a Cellular Metabolic Network |
| Author: |
Vitkup, Dennis; Kharchenko, Peter Vasili; Church, George McDonald
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Kharchenko, Peter V., George M. Church, and Dennis Vitkup. 2005. Expression dynamics of a cellular metabolic network. Molecular Systems Biology 1: 2005.0016. |
| Full Text & Related Files: |
1681454.pdf (130.7Kb; PDF) 
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| Abstract: | Toward the goal of understanding system properties of biological networks, we investigate the global and local regulation of gene expression in the Saccharomyces cerevisiae metabolic network. Our results demonstrate predominance of local gene regulation in metabolism. Metabolic genes display significant coexpression on distances smaller than the average network distance, a behavior supported by the distribution of transcription factor binding sites in the metabolic network and genome context associations. Positive gene coexpression decreases monotonically with distance in the network, while negative coexpression is strongest at intermediate network distances. We show that basic topological motifs of the metabolic network exhibit statistically significant differences in coexpression behavior. |
| Published Version: | doi:10.1038/msb4100023 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681454/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4724182 |
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