Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

DSpace/Manakin Repository

Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Show simple item record

dc.contributor.author Cheng, Ching-Yu
dc.contributor.author Wong, Tien Y.
dc.contributor.author Klein, Ronald
dc.contributor.author Klein, Barbara E. K.
dc.contributor.author Patterson, Nick
dc.contributor.author Li, Man
dc.contributor.author Boerwinkle, Eric
dc.contributor.author Sharrett, A. Richey
dc.contributor.author Reich, David Emil
dc.contributor.author Tandon, Arti
dc.contributor.author Kao, W. H. Linda
dc.date.accessioned 2011-02-14T23:29:25Z
dc.date.issued 2010
dc.identifier.citation Cheng, Ching-Yu, David Reich, Tien Y. Wong, Ronald Klein, Barbara E. K. Klein, Nick Patterson, Arti Tandon, et al. 2010. Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) Study. PLoS Genetics 6(4): e1000908. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4725500
dc.description.abstract Retinal vascular caliber provides information about the structure and health of the microvascular system and is associated with cardiovascular and cerebrovascular diseases. Compared to European Americans, African Americans tend to have wider retinal arteriolar and venular caliber, even after controlling for cardiovascular risk factors. This has suggested the hypothesis that differences in genetic background may contribute to racial/ethnic differences in retinal vascular caliber. Using 1,365 ancestry-informative SNPs, we estimated the percentage of African ancestry (PAA) and conducted genome-wide admixture mapping scans in 1,737 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) representing summary measures of retinal arteriolar and venular caliber, respectively, were measured from retinal photographs. PAA was significantly correlated with CRVE (ρ = 0.071, P = 0.003), but not CRAE (ρ = 0.032, P = 0.182). Using admixture mapping, we did not detect significant admixture association with either CRAE (genome-wide score = −0.73) or CRVE (genome-wide score = −0.69). An a priori subgroup analysis among hypertensive individuals detected a genome-wide significant association of CRVE with greater African ancestry at chromosome 6p21.1 (genome-wide score = 2.31, locus-specific LOD = 5.47). Each additional copy of an African ancestral allele at the 6p21.1 peak was associated with an average increase in CRVE of 6.14 µm in the hypertensives, but had no significant effects in the non-hypertensives (P for heterogeneity <0.001). Further mapping in the 6p21.1 region may uncover novel genetic variants affecting retinal vascular caliber and further insights into the interaction between genetic effects of the microvascular system and hypertension. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1000908 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855324/pdf/ en_US
dash.license LAA
dc.subject cardiovascular disorders en_US
dc.subject hypertension en_US
dc.subject peripheral vascular disease en_US
dc.subject evolutionary biology en_US
dc.subject genomics en_US
dc.subject genetics and genomics en_US
dc.subject complex traits en_US
dc.subject population genetics en_US
dc.subject ophthalmology en_US
dc.subject retinal disorders en_US
dc.subject public health and epidemiology en_US
dc.subject epidemiology en_US
dc.title Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: The Atherosclerosis Risk in Communities (ARIC) Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author Reich, David Emil
dc.date.available 2011-02-14T23:29:25Z
dash.affiliation.other HMS^Genetics en_US
dash.affiliation.other HMS^Genetics en_US

Files in this item

Files Size Format View
2855324.pdf 297.4Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters