Global Gene Expression of Prochlorococcus ecotypes in Response to Changes in Nitrogen Availability

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Global Gene Expression of Prochlorococcus ecotypes in Response to Changes in Nitrogen Availability

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dc.contributor.author Lindell, Debbie
dc.contributor.author Johnson, Zackary I
dc.contributor.author Rector, Trent
dc.contributor.author Chisholm, Sallie W
dc.contributor.author Tolonen, Andrew
dc.contributor.author Aach, John Dennis
dc.contributor.author Steen, Robert G.
dc.date.accessioned 2011-02-15T00:17:24Z
dc.date.issued 2006
dc.identifier.citation Tolonen, Andrew C., John Aach, Debbie Lindell, Zackary I. Johnson, Trent Rector, Robert Steen, George M. Church, and Sallie W. Chisholm. 2006. Global gene expression of Prochlorococcus ecotypes in response to changes in nitrogen availability. Molecular Systems Biology 2: 53. en_US
dc.identifier.issn 1744-4292 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4725512
dc.description.abstract Nitrogen (N) often limits biological productivity in the oceanic gyres where Prochlorococcus is the most abundant photosynthetic organism. The Prochlorococcus community is composed of strains, such as MED4 and MIT9313, that have different N utilization capabilities and that belong to ecotypes with different depth distributions. An interstrain comparison of how Prochlorococcus responds to changes in ambient nitrogen is thus central to understanding its ecology. We quantified changes in MED4 and MIT9313 global mRNA expression, chlorophyll fluorescence, and photosystem II photochemical efficiency (Fv/Fm) along a time series of increasing N starvation. In addition, the global expression of both strains growing in ammonium-replete medium was compared to expression during growth on alternative N sources. There were interstrain similarities in N regulation such as the activation of a putative NtcA regulon during N stress. There were also important differences between the strains such as in the expression patterns of carbon metabolism genes, suggesting that the two strains integrate N and C metabolism in fundamentally different ways. en_US
dc.language.iso en_US en_US
dc.publisher European Molecular Biology Organization en_US
dc.relation.isversionof doi:10.1038/msb4100087 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682016/pdf/ en_US
dash.license LAA
dc.subject cyanobacteria en_US
dc.subject interstrain en_US
dc.subject nitrogen en_US
dc.subject Prochlorococcus en_US
dc.subject transcription en_US
dc.title Global Gene Expression of Prochlorococcus ecotypes in Response to Changes in Nitrogen Availability en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Molecular Systems Biology en_US
dash.depositing.author Aach, John Dennis
dc.date.available 2011-02-15T00:17:24Z
dash.affiliation.other HMS^Genetics en_US
dash.affiliation.other HMS^Genetics en_US
dash.affiliation.other HMS^Health Sciences and Technology en_US
dash.affiliation.other HMS^Genetics en_US

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