Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols.

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Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols.

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Title: Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols.
Author: Kopecky, David J.; Yang, Bryant H.; Myers, Andrew G.

Note: Order does not necessarily reflect citation order of authors.

Citation: Myers, Andrew G., Bryant Yang, and David Kopecky. 1996. Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols. Tetrahedron Letters 37, no. 21: 3623-3626.
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Abstract: Lithium amidotrihydroborate (LiH3NBH3, LAB) is a new and highly nucleophilic reducing agent that is easily prepared by deprotonation of the commercial reagent borane-ammonia complex (H3NBH3) with n-BuLi in tetrahydrofuran (THF) at 0 degrees C. LAB is found to be a superior reagent for the transformation of tertiary amides into the corresponding primary alcohols.
Published Version: http://dx.doi.org/10.1016/0040-4039(96)00652-1
Other Sources: http://www.chem.harvard.edu/groups/myers/pdf_publications/tetlet_1996_37_3632.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4725865

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  • FAS Scholarly Articles [7103]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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