Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy
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Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy
| Title: | Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy |
| Author: |
Shao, Wenlin; Brown, Myles Avery
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Shao, Wenlin, and Myles Brown. 2004. Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Research 6(1): 39-52. |
| Full Text & Related Files: |
314456.pdf (375.6Kb; PDF) 
|
| Abstract: | Estrogen receptor (ER) has a crucial role in normal breast development and is expressed in the most common breast cancer subtypes. Importantly, its expression is very highly predictive for response to endocrine therapy. Current endocrine therapies for ER-positive breast cancers target ER function at multiple levels. These include targeting the level of estrogen, blocking estrogen action at the ER, and decreasing ER levels. However, the ultimate effectiveness of therapy is limited by either intrinsic or acquired resistance. Identifying the factors and pathways responsible for sensitivity and resistance remains a challenge in improving the treatment of breast cancer. With a better understanding of coordinated action of ER, its coregulatory factors, and the influence of other intracellular signaling cascades, improvements in breast cancer therapy are emerging. |
| Published Version: | doi://10.1186/bcr742 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314456/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4727702 |
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