Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy

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Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy

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dc.contributor.author Shao, Wenlin
dc.contributor.author Brown, Myles Avery
dc.date.accessioned 2011-02-18T16:58:22Z
dc.date.issued 2003
dc.identifier.citation Shao, Wenlin, and Myles Brown. 2004. Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Research 6(1): 39-52. en_US
dc.identifier.issn 1465-5411 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4727702
dc.description.abstract Estrogen receptor (ER) has a crucial role in normal breast development and is expressed in the most common breast cancer subtypes. Importantly, its expression is very highly predictive for response to endocrine therapy. Current endocrine therapies for ER-positive breast cancers target ER function at multiple levels. These include targeting the level of estrogen, blocking estrogen action at the ER, and decreasing ER levels. However, the ultimate effectiveness of therapy is limited by either intrinsic or acquired resistance. Identifying the factors and pathways responsible for sensitivity and resistance remains a challenge in improving the treatment of breast cancer. With a better understanding of coordinated action of ER, its coregulatory factors, and the influence of other intracellular signaling cascades, improvements in breast cancer therapy are emerging. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/bcr742 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314456/pdf/ en_US
dash.license LAA
dc.subject coregulators en_US
dc.subject estrogen receptor en_US
dc.subject growth factors en_US
dc.subject SERM en_US
dc.subject tamoxifen resistance en_US
dc.title Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Breast Cancer Research en_US
dash.depositing.author Brown, Myles Avery
dc.date.available 2011-02-18T16:58:22Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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