Mapping the Structural Core of Human Cerebral Cortex

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Mapping the Structural Core of Human Cerebral Cortex

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Title: Mapping the Structural Core of Human Cerebral Cortex
Author: Hagmann, Patric; Cammoun, Leila; Gigandet, Xavier; Meuli, Reto; Honey, Christopher J; Sporns, Olaf; Wedeen, Van Jay

Note: Order does not necessarily reflect citation order of authors.

Citation: Hagmann, Patric, Leila Cammoun, Xavier Gigandet, Reto Meuli, Christopher J Honey, Van J. Wedeen, and Olaf Sporns. 2008. Mapping the Structural Core of Human Cerebral Cortex. PLoS Biology 6(7): e159.
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Abstract: Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration.
Published Version: doi:10.1371/journal.pbio.0060159
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443193/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4728517

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