Data for Genetic Analysis Workshop (GAW) 15 Problem 2, Genetic Causes of Rheumatoid Arthritis and Associated Traits

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Data for Genetic Analysis Workshop (GAW) 15 Problem 2, Genetic Causes of Rheumatoid Arthritis and Associated Traits

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dc.contributor.author Amos, Christopher I
dc.contributor.author Remmers, Elaine
dc.contributor.author Siminovitch, Katherine A
dc.contributor.author Seldin, Michael F
dc.contributor.author Criswell, Lindsey A
dc.contributor.author Lee, Annette T
dc.contributor.author John, Sally
dc.contributor.author Shephard, Neil D
dc.contributor.author Worthington, Jane
dc.contributor.author Cornelis, Francois
dc.contributor.author Begovich, Ann B
dc.contributor.author Dyer, Thomas D
dc.contributor.author Kastner, Daniel L
dc.contributor.author Gregersen, Peter K
dc.contributor.author Plenge, Robert M.
dc.contributor.author Chen, Wei Vivien
dc.date.accessioned 2011-02-22T00:10:32Z
dc.date.issued 2007
dc.identifier.citation Amos, Christopher I., Wei Vivien Chen, Elaine Remmers, Katherine A. Siminovitch, Michael F. Seldin, Lindsey A. Criswell, Annette T. Lee, et al. 2007. Data for genetic analysis workshop (GAW) 15 problem 2, genetic causes of rheumatoid arthritis and associated traits. BMC Proceedings 1(Suppl 1): S3. en_US
dc.identifier.issn 1753-6561 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4728740
dc.description.abstract For Genetic Analysis Workshop 15 Problem 2, we organized data from several ongoing studies designed to identify genetic and environmental risk factors for rheumatoid arthritis. Data were derived from the North American Rheumatoid Arthritis Consortium (NARAC), collaboration among Canadian researchers, the European Consortium on Rheumatoid Arthritis Families (ECRAF), and investigators from Manchester, England. All groups used a common standard for defining rheumatoid arthritis, but NARAC also further selected for a more severe phenotype in the probands. Genotyping and family structures for microsatellite-based linkage analysis were provided from all centers. In addition, all centers but ECRAF have genotyped families for linkage analysis using SNPs and these data were additionally provided. NARAC also had additional data from a dense genotyping analysis of a region of chromosome 18 and results from candidate gene studies, which were provided. Finally, smoking influences risk for rheumatoid arthritis, and data were provided from the NARAC study on this behavior as well as some additional phenotypes measuring severity. Several questions could be evaluated using the data that were provided. These include comparing linkage analysis using single-nucleotide polymorphisms versus microsatellites and identifying credible regions of linkage outside the HLA region on chromosome 6p13, which has been extensively documented; evaluating the joint effects of smoking with genetic factors; and identifying more homogenous subsets of families for whom genetic susceptibility might be stronger, so that linkage and association studies may be more efficiently conducted. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof http://www.biomedcentral.com/1753-6561/1/S1/S3 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367518/pdf/ en_US
dash.license LAA
dc.title Data for Genetic Analysis Workshop (GAW) 15 Problem 2, Genetic Causes of Rheumatoid Arthritis and Associated Traits en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Proceedings en_US
dash.depositing.author Plenge, Robert M.
dc.date.available 2011-02-22T00:10:32Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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