p190RhoGAP is the convergence point of adhesion signals from α_5β_1 integrin and syndecan-4

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p190RhoGAP is the convergence point of adhesion signals from α_5β_1 integrin and syndecan-4

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Title: p190RhoGAP is the convergence point of adhesion signals from α_5β_1 integrin and syndecan-4
Author: Bass, Mark D.; Morgan, Mark R.; Roach, Kirsty A.; Settleman, Jeffrey Evan; Goryachev, Andrew B.; Humphries, Martin J.

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Citation: Bass, Mark D., Mark R. Morgan, Kirsty A. Roach, Jeffrey Settleman, Andrew B. Goryachev, and Martin J. Humphries. 2008. p190RhoGAP is the convergence point of adhesion signals from α_5β_1 integrin and syndecan-4. The Journal of Cell Biology 181(6): 1013-1026.
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Abstract: The fibronectin receptors α_5β_1 integrin and syndecan-4 cocluster in focal adhesions and coordinate cell migration by making individual contributions to the suppression of RhoA activity during matrix engagement. p190Rho–guanosine triphosphatase–activating protein (GAP) is known to inhibit RhoA during the early stages of cell spreading in an Src-dependent manner. This paper dissects the mechanisms of p190RhoGAP regulation and distinguishes the contributions of α_5β_1 integrin and syndecan-4. Matrix-induced tyrosine phosphorylation of p190RhoGAP is stimulated solely by engagement of α_5β_1 integrin and is independent of syndecan-4. Parallel engagement of syndecan-4 causes redistribution of the tyrosine-phosphorylated pool of p190RhoGAP between membrane and cytosolic fractions by a mechanism that requires direct activation of protein kinase C α by syndecan-4. Activation of both pathways is necessary for the efficient regulation of RhoA and, as a consequence, focal adhesion formation. Accordingly, we identify p190RhoGAP as the convergence point for adhesive signals mediated by α_5β_1 integrin and syndecan-4. This molecular mechanism explains the cooperation between extracellular matrix receptors during cell adhesion.
Published Version: doi:10.1083/jcb.200711129
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426943/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4737468

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