The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

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The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

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Title: The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics
Author: Yu, Haiyuan; Kim, Philip M.; Sprecher, Emmett; Trifonov, Valery; Gerstein, Mark

Note: Order does not necessarily reflect citation order of authors.

Citation: Yu, Haiyuan, Philip M. Kim, Emmett Sprecher, Valery Trifonov, and Mark Gerstein. 2007. The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics. PLoS Computational Biology 3(4): e59.
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Abstract: It has been a long-standing goal in systems biology to find relations between the topological properties and functional features of protein networks. However, most of the focus in network studies has been on highly connected proteins (“hubs”). As a complementary notion, it is possible to define bottlenecks as proteins with a high betweenness centrality (i.e., network nodes that have many “shortest paths” going through them, analogous to major bridges and tunnels on a highway map). Bottlenecks are, in fact, key connector proteins with surprising functional and dynamic properties. In particular, they are more likely to be essential proteins. In fact, in regulatory and other directed networks, betweenness (i.e., “bottleneck-ness”) is a much more significant indicator of essentiality than degree (i.e., “hub-ness”). Furthermore, bottlenecks correspond to the dynamic components of the interaction network—they are significantly less well coexpressed with their neighbors than nonbottlenecks, implying that expression dynamics is wired into the network topology.
Published Version: doi:10.1371/journal.pcbi.0030059
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853125/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4737476

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