A Major Genetic Locus Controlling Natural Plasmodium falciparum Infection is Shared by East and West African Anopheles gambiae

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A Major Genetic Locus Controlling Natural Plasmodium falciparum Infection is Shared by East and West African Anopheles gambiae

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dc.contributor.author Riehle, Michelle M
dc.contributor.author Lambrechts, Louis
dc.contributor.author Xia, Ai
dc.contributor.author Sharakhov, Igor
dc.contributor.author Koella, Jacob C
dc.contributor.author Vernick, Kenneth D
dc.contributor.author Markianos, Kyriacos
dc.date.accessioned 2011-03-08T18:05:26Z
dc.date.issued 2007
dc.identifier.citation Riehle, Michelle M., Kyriacos Markianos, Louis Lambrechts, Ai Xia, Igor Sharakhov, Jacob C. Koella, and Kenneth D. Vernick. 2007. A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae. Malaria Journal 6: 87. en_US
dc.identifier.issn 1475-2875 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4739278
dc.description.abstract Background: Genetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum. This 2L Plasmodium-resistance interval was mapped in mosquitoes from a natural population in Mali, West Africa, and controls the numbers of P. falciparum oocysts that develop on the vector midgut. An important question is whether genetic variation with respect to Plasmodium-resistance exists across Africa, and if so whether the same or multiple geographically distinct resistance mechanisms are responsible for the trait. Methods: To identify P falciparum resistance loci in pedigrees generated and infected in Kenya, East Africa, 28 microsatellite loci were typed across the mosquito genome. Genetic linkage mapping was used to detect significant linkage between genotype and numbers of midgut oocysts surviving to 7–8 days post-infection. Results: A major malaria-control locus was identified on chromosome 2L in East African mosquitoes, in the same apparent position originally identified from the West African population. Presence of this resistance locus explains 75% of parasite free mosquitoes. The Kenyan resistance locus is named EA_Pfin1 (East Africa_ Plasmodium falciparum Infection Intensity). Conclusion: Detection of a malaria-control locus at the same chromosomal location in both East and West African mosquitoes indicates that, to the level of genetic resolution of the analysis, the same mechanism of Plasmodium-resistance, or a mechanism controlled by the same genomic region, is found across Africa, and thus probably operates in A. gambiae throughout its entire range. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/1475-2875-6-87 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936428/pdf/ en_US
dash.license LAA
dc.title A Major Genetic Locus Controlling Natural Plasmodium falciparum Infection is Shared by East and West African Anopheles gambiae en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Malaria Journal en_US
dash.depositing.author Markianos, Kyriacos
dc.date.available 2011-03-08T18:05:26Z
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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