An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants

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An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants

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Title: An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants
Author: Miranda, Kevin C.; Karet, Fiona E.; Ruttenberg, Alan; Brown, Dennis

Note: Order does not necessarily reflect citation order of authors.

Citation: Miranda, Kevin C., Fiona E. Karet, and Dennis Brown. 2010. An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants. PLoS ONE 5(3).
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Abstract: The vacuolar-type H+-ATPase (V-ATPase) is a multisubunit proton pump that is involved in both intra- and extracellular acidification processes throughout the body. Multiple homologs and splice variants of V-ATPase subunits are thought to explain its varied spatial and temporal expression pattern in different cell types. Recently subunit nomenclature was standardized with a total of 22 subunit variants identified. However this standardization did not accommodate the existence of splice variants and is therefore incomplete. Thus, we propose here an extension of subunit nomenclature along with a literature and sequence database scan for additional V-ATPase subunits. An additional 17 variants were pulled from a literature search while 4 uncharacterized potential subunit variants were found in sequence databases. These findings have been integrated with the current V-ATPase knowledge base to create a new V-ATPase subunit catalogue. It is envisioned this catalogue will form a new platform on which future studies into tissue- and organelle-specific V-ATPase expression, localization and function can be based.
Published Version: doi://10.1371/journal.pone.0009531
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835735/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4740119

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