Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase

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Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase

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dc.contributor.author Inman, Syed Z.
dc.contributor.author Indig, Fred E.
dc.contributor.author Cheng, Wen-Hsing
dc.contributor.author Saxena, Satya P.
dc.contributor.author Stevnsner, Tinna
dc.contributor.author Kufe, Donald William
dc.contributor.author Bohr, Vilhelm A.
dc.date.accessioned 2011-03-15T13:33:42Z
dc.date.issued 2007
dc.identifier.citation Imam, Syed Z., Fred E. Indig, Wen-Hsing Cheng, Satya P. Saxena, Tinna Stevnsner, Donald Kufe, and Vilhelm A. Bohr. 2007. Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. Nucleic Acids Research 35(15): 4941-4951. en_US
dc.identifier.issn 0305-1048 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4741826
dc.description.abstract The Cockayne Syndrome group B (CSB) protein plays important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair. c-Abl kinase also plays a role in DNA repair as a regulator/coordinator of the DNA damage response. This study presents evidence that the N-terminal region of CSB interacts with the SH3 domain of c-Abl in vitro and in vivo. In addition, c-Abl kinase phosphorylates CSB at Tyr932. The subcellular localization of CSB to the nucleus and nucleolus is altered after phosphorylation by c-Abl. c-Abl-dependent phosphorylation of CSB increased in cells treated with hydrogen peroxide and decreased in cells pre-treated with STI-571, a c-Abl-specific protein kinase inhibitor. Activation of the c-Abl kinase in response to oxidative damage is not observed in CSB null cells. These results suggest that c-Abl and CSB may regulate each other in a reciprocal manner in response to oxidative stress. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi://10.1093/nar/gkm386 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976445/pdf/ en_US
dash.license LAA
dc.subject DNA damage en_US
dc.subject oxidative stress en_US
dc.subject apoptotic response en_US
dc.subject induce apoptosis en_US
dc.subject cellular repair en_US
dc.subject excision-repair en_US
dc.subject active genes en_US
dc.subject 8-hydroxyadenine en_US
dc.subject activation en_US
dc.title Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Nucleic Acids Research en_US
dash.depositing.author Kufe, Donald William
dc.date.available 2011-03-15T13:33:42Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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