Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice

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Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice

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dc.contributor.author Yamaguchi, Hiroo
dc.contributor.author Shen, Jie
dc.date.accessioned 2011-03-18T18:34:45Z
dc.date.issued 2007
dc.identifier.citation Yamaguchi, Hiroo, and Jie Shen. 2007. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular Neurodegeneration 2:10. en_US
dc.identifier.issn 1750-1326 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4744869
dc.description.abstract Parkinson's disease is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. Loss-of-function mutations in the DJ-1 gene have been linked to autosomal recessive forms of early-onset familial Parkinson's disease. DJ-1 is thought to play roles in protection of cells against oxidative stress and in maintenance of the normal dopaminergic function in the nigrostriatal pathway. Here we investigate the consequence of both DJ-1 inactivation and aging in mice. We found that DJ-1-/- mice at the age of 24–27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. The number of noradrenergic neurons in the locus coeruleus is also unchanged in DJ-1-/- mice. Moreover, there is no accumulation of oxidative damage or inclusion bodies in aged DJ-1-/- brains. Together, these results indicate that loss of DJ-1 function alone is insufficient to cause nigral degeneration and oxidative damage in the life span of mice. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1750-1326-2-10 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891294/pdf/ en_US
dash.license LAA
dc.title Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Molecular Neurodegeneration en_US
dash.depositing.author Yamaguchi, Hiroo
dc.date.available 2011-03-18T18:34:45Z
dash.affiliation.other HMS^Neurology-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Neurology-Brigham and Women's Hospital en_US

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