Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice

Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice

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Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice

dc.contributor.author	Yamaguchi, Hiroo
dc.contributor.author	Shen, Jie
dc.date.accessioned	2011-03-18T18:34:45Z
dc.date.issued	2007
dc.identifier.citation	Yamaguchi, Hiroo, and Jie Shen. 2007. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular Neurodegeneration 2:10.	en_US
dc.identifier.issn	1750-1326	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4744869
dc.description.abstract	Parkinson's disease is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. Loss-of-function mutations in the DJ-1 gene have been linked to autosomal recessive forms of early-onset familial Parkinson's disease. DJ-1 is thought to play roles in protection of cells against oxidative stress and in maintenance of the normal dopaminergic function in the nigrostriatal pathway. Here we investigate the consequence of both DJ-1 inactivation and aging in mice. We found that DJ-1-/- mice at the age of 24–27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. The number of noradrenergic neurons in the locus coeruleus is also unchanged in DJ-1-/- mice. Moreover, there is no accumulation of oxidative damage or inclusion bodies in aged DJ-1-/- brains. Together, these results indicate that loss of DJ-1 function alone is insufficient to cause nigral degeneration and oxidative damage in the life span of mice.	en_US
dc.language.iso	en_US	en_US
dc.publisher	BioMed Central	en_US
dc.relation.isversionof	doi:10.1186/1750-1326-2-10	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891294/pdf/	en_US
dash.license	LAA
dc.title	Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Molecular Neurodegeneration	en_US
dash.depositing.author	Yamaguchi, Hiroo
dc.date.available	2011-03-18T18:34:45Z
dash.affiliation.other	HMS^Neurology-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Neurology-Brigham and Women's Hospital	en_US