Systems Engineering to Systems Biology

DSpace/Manakin Repository

. . . . . .

Title:	Systems Engineering to Systems Biology
Author:	Yıldırım, Muhammed A; Vidal, Marc Note: Order does not necessarily reflect citation order of authors.
Citation:	Yıldırım, Muhammed A., and Marc Vidal. 2008. Systems engineering to systems biology. Molecular Systems Biology 4: 185.
Full Text & Related Files:	2387234.pdf (86.78Kb; PDF)
Abstract:	No abstract provided. First paragraph: The ‘bottom-up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top-down’ fashion, using a variety of network reverse engineering methods, data-driven modeling and data integration strategies. Application of a top-down approach to the quantitative biology of a small size system is however less common. In a recent publication, Mettetal et al (2008) have insightfully applied such a strategy to successfully decode critical properties of osmo-adaptation in the yeast Saccharomyces cerevisiae.
Published Version:	doi:10.1038/msb.2008.22
Other Sources:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387234/pdf/
Terms of Use:	This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4750534