Surgical Impact on Brain Tumor Invasion: A Physical Perspective

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Surgical Impact on Brain Tumor Invasion: A Physical Perspective

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Title: Surgical Impact on Brain Tumor Invasion: A Physical Perspective
Author: Guiot, Caterina; Deisboeck, Thomas Steve

Note: Order does not necessarily reflect citation order of authors.

Citation: Deisboeck, Thomas S., and Caterina Guiot. 2008. Surgical impact on brain tumor invasion: a physical perspective. Annals of Surgical Innovation and Research 2:1.
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Abstract: It is conventional strategy to treat highly malignant brain tumors initially with cytoreductive surgery followed by adjuvant radio- and chemotherapy. However, in spite of all such efforts, the patients' prognosis remains dismal since residual glioma cells continue to infiltrate adjacent parenchyma and the tumors almost always recur. On the basis of a simple biomechanical conjecture that we have introduced previously, we argue here that by affecting the 'volume-pressure' relationship and minimizing surface tension of the remaining tumor cells, gross total resection may have an inductive effect on the invasiveness of the tumor cells left behind. Potential implications for treatment strategies are discussed.
Published Version: doi:10.1186/1750-1164-2-1
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359755/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4774097

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