The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance

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The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance

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dc.contributor.author Sévigny, Jean
dc.contributor.author Zimmermann, Herbert
dc.contributor.author Robson, Simon Christopher
dc.date.accessioned 2011-04-08T14:38:52Z
dc.date.issued 2006
dc.identifier.citation Robson, Simon C., Jean Sévigny, and Herbert Zimmermann. 2006. The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signalling 2, no. 2: 409-430. en_US
dc.identifier.issn 1573-9538 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4817312
dc.description.abstract Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized. In this article, we specifically address the cell surface-located members of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase/CD39) family (NTPDase1,2,3, and 8). The molecular identification of individual NTPDase subtypes, genetic engineering, mutational analyses, and the generation of subtype-specific antibodies have resulted in considerable insights into enzyme structure and function. These advances also allow definition of physiological and patho-physiological implications of NTPDases in a considerable variety of tissues. Biological actions of NTPDases are a consequence (at least in part) of the regulated phosphohydrolytic activity on extracellular nucleotides and consequent effects on P2-receptor signaling. It further appears that the spatial and temporal expression of NTPDases by various cell types within the vasculature, the nervous tissues and other tissues impacts on several patho-physiological processes. Examples include acute effects on cellular metabolism, adhesion, activation and migration with other protracted impacts upon developmental responses, inclusive of cellular proliferation, differentiation and apoptosis, as seen with atherosclerosis, degenerative neurological diseases and immune rejection of transplanted organs and cells. Future clinical applications are expected to involve the development of new therapeutic strategies for transplantation and various inflammatory cardiovascular, gastrointestinal and neurological diseases. en_US
dc.language.iso en_US en_US
dc.publisher Springer Netherlands en_US
dc.relation.isversionof doi://10.1007/s11302-006-9003-5 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254478/pdf/ en_US
dash.license LAA
dc.subject apyrase en_US
dc.subject brain en_US
dc.subject CD39 en_US
dc.subject ecto-ATPase en_US
dc.subject immunology en_US
dc.subject ischemia en_US
dc.subject kidney en_US
dc.subject liver en_US
dc.subject nervous tissue en_US
dc.subject NTPDase en_US
dc.subject platelet en_US
dc.subject vasculature en_US
dc.title The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Purinergic Signalling en_US
dash.depositing.author Robson, Simon Christopher
dc.date.available 2011-04-08T14:38:52Z
dash.affiliation.other HMS^Medicine- Beth Israel-Deaconess en_US

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