Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice

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Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice

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Title: Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice
Author: Jimenez-Chillaron, Jose; Chow, Alice; DeCoste, Jennifer; Vokes, Martha; Liu, Manway; Kasif, Simon; Zavacki, Ann-Marie; Leshan, Rebecca L.; Myers, Martin G.; Isganaitis, Elvira; Woo, Melissa; Patti, Mary-Elizabeth

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Citation: Isganaitis, Elvira, Jose Jimenez-Chillaron, Melissa Woo, Alice Chow, Jennifer DeCoste, Martha Vokes, Manway Liu, et al. 2009. Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes 58(5): 1192-1200.
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Abstract: OBJECTIVE: To characterize the hormonal milieu and adipose gene expression in response to catch-up growth (CUG), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (LBW). RESEARCH DESIGN AND METHODS: ICR mice were food restricted by 50% from gestational days 12.5–18.5, reducing offspring birth weight by 25%. During the suckling period, dams were either fed ad libitum, permitting CUG in offspring, or food restricted, preventing CUG. Offspring were killed at age 3 weeks, and gonadal fat was removed for RNA extraction, array analysis, RT-PCR, and evaluation of cell size and number. Serum insulin, thyroxine (T4), corticosterone, and adipokines were measured. RESULTS: At age 3 weeks, LBW mice with CUG (designated U-C) had body weight comparable with controls (designated C-C); weight was reduced by 49% in LBW mice without CUG (designated U-U). Adiposity was altered by postnatal nutrition, with gonadal fat increased by 50% in U-C and decreased by 58% in U-U mice (P less than 0.05 vs. C-C mice). Adipose expression of the lipogenic genes Fasn, AccI, Lpin1, and Srebf1 was significantly increased in U-C compared with both C-C and U-U mice (P less than 0.05). Mitochondrial DNA copy number was reduced by greater than 50% in U-C versus U-U mice (P = 0.014). Although cell numbers did not differ, mean adipocyte diameter was increased in U-C and reduced in U-U mice (P less than 0.01). CONCLUSIONS: CUG results in increased adipose tissue lipogenic gene expression and adipocyte diameter but not increased cellularity, suggesting that catch-up fat is primarily associated with lipogenesis rather than adipogenesis in this murine model.
Published Version: doi:10.2337/db08-1266
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671035/pdf/
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4817606

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