Retaining Residual Ovarian Tissue Following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice

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Retaining Residual Ovarian Tissue Following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice

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Title: Retaining Residual Ovarian Tissue Following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice
Author: Craig, Zelieann R.; Marion, Samuel L.; Funk, Janet L.; Hoyer, Patricia B.; Bouxsein, Mary Larsen

Note: Order does not necessarily reflect citation order of authors.

Citation: Craig, Zelieann R., Samuel L. Marion, Janet L. Funk, Mary L. Bouxsein, and Patricia B. Hoyer. 2010. Retaining residual ovarian tissue following ovarian failure has limited influence on bone loss in aged mice. Journal of Osteoporosis 2010.
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Abstract: Previous work showed that retaining residual ovarian tissue protects young mice from accelerated bone loss following ovarian failure. The present study was designed to determine whether this protection is also present in aged animals. Aged (9–12 months) C57BL/6Hsd female mice were divided into: CON (vehicle), VCD (160 mg/kg; 15d), or OVX (ovariectomized). Lumbar BMD was monitored by DXA and μCT used to assess vertebral microarchitecture. BMD was not different between VCD and CON at any time point but was lower (P < .05) than baseline, starting 1 month after ovarian failure in VCD and OVX mice. Following μCT analysis there were no differences between CON and VCD, but OVX mice had lower bone volume fraction, trabecular thickness, and a trend for decreased connectivity density. These findings provide evidence that retention of residual ovarian tissue may protect aged follicle-depleted mice from accelerated bone loss to a lesser extent than that observed in young mice.
Published Version: doi:10.4061/2010/157323
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951122/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4853360

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