Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16Ink4a Mutations

DSpace/Manakin Repository

Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16Ink4a Mutations

Show simple item record

dc.contributor.author Kalamarides, Michel
dc.contributor.author Takahashi, Masaya
dc.contributor.author Han, Zhi-Yan
dc.contributor.author Chareyre, Fabrice
dc.contributor.author Niwa-Kawakita, Michiko
dc.contributor.author Giovannini, Marco
dc.contributor.author Stemmer-Rachamimov, Anat
dc.contributor.author Black, Peter McLaren
dc.contributor.author Carroll, Rona Stephanie
dc.date.accessioned 2011-04-18T02:55:53Z
dc.date.issued 2008
dc.identifier.citation Kalamarides, Michel, Anat O. Stemmer-Rachamimov, Masaya Takahashi, Zhi-Yan Han, Fabrice Chareyre, Michiko Niwa-Kawakita, Peter M. Black, Rona S. Carroll, and Marco Giovannini. 2008. Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16Ink4a Mutations. Brain Pathology (Zurich, Switzerland) 18(1): 62-70. en_US
dc.identifier.issn 1015-6305 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4853408
dc.description.abstract Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using magnetic resonance imaging (MRI) to screen a large cohort of mutant mice, we were able to detect meningothelial proliferation and meningioma development opening the way to future studies in which therapeutic interventions can be tested as preclinical assessment of their potential clinical application. en_US
dc.language.iso en_US en_US
dc.publisher Blackwell Publishing Ltd en_US
dc.relation.isversionof doi:10.1111/j.1750-3639.2007.00105.x en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253711/pdf/ en_US
dash.license LAA
dc.title Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16Ink4a Mutations en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Brain Pathology (Zurich, Switzerland) en_US
dash.depositing.author Stemmer-Rachamimov, Anat
dc.date.available 2011-04-18T02:55:53Z
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Surgery-Children's Hospital en_US
dash.affiliation.other HMS^Surgery-Children's Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

Files in this item

Files Size Format View
2253711.pdf 640.9Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters