dc.contributor.author | Medina-Ramón, Mercedes | |
dc.contributor.author | Zanobetti, Antonella | |
dc.contributor.author | Cavanagh, David Paul | |
dc.contributor.author | Schwartz, Joel David | |
dc.date.accessioned | 2011-04-22T19:24:04Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Medina-Ramón, Mercedes, Antonella Zanobetti, David Paul Cavanagh, and Joel Schwartz. 2006. Extreme Temperatures and Mortality: Assessing Effect Modification by Personal Characteristics and Specific Cause of Death in a Multi-City Case-Only Analysis. Environmental Health Perspectives 114(9): 1331-1336. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874477 | |
dc.description.abstract | Background: Extremes of temperature are associated with short-term increases in daily mortality. Objectives: We set out to identify subpopulations and mortality causes with increased susceptibility to temperature extremes. Methods: We conducted a case-only analysis using daily mortality and hourly weather data from 50 U.S. cities for the period 1989–2000, covering a total of 7,789,655 deaths. We used distributions of daily minimum and maximum temperature in each city to define extremely hot days (≥ 99th percentile) and extremely cold days (≤ 1st percentile), respectively. For each (hypothesized) effect modifier, a city-specific logistic regression model was fitted and an overall estimate calculated in a subsequent meta-analysis. Results: Older subjects [odds ratio (OR) = 1.020; 95% confidence interval (CI), 1.005–1.034], diabetics (OR = 1.035; 95% CI, 1.010–1.062), blacks (OR = 1.037; 95% CI, 1.016–1.059), and those dying outside a hospital (OR = 1.066; 95% CI, 1.036–1.098) were more susceptible to extreme heat, with some differences observed between those dying from a cardiovascular disease and other decedents. Cardiovascular deaths (OR = 1.053; 95% CI, 1.036–1.070), and especially cardiac arrest deaths (OR =1.137; 95% CI, 1.051–1.230), showed a greater relative increase on extremely cold days, whereas the increase in heat-related mortality was marginally higher for those with coexisting atrial fibrillation (OR = 1.059; 95% CI, 0.996–1.125). Conclusions: In this study we identified several subpopulations and mortality causes particularly susceptible to temperature extremes. This knowledge may contribute to establishing health programs that would better protect the vulnerable. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi:10.1289/ehp.9074 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570054/pdf/ | en_US |
dash.license | LAA | |
dc.subject | cause of death | en_US |
dc.subject | cold | en_US |
dc.subject | effect modifiers (epidemiology) | en_US |
dc.subject | heat | en_US |
dc.subject | mortality | en_US |
dc.subject | temperature | en_US |
dc.subject | weather | en_US |
dc.title | Extreme Temperatures and Mortality: Assessing Effect Modification by Personal Characteristics and Specific Cause of Death in a Multi-City Case-Only Analysis | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Schwartz, Joel David | |
dc.date.available | 2011-04-22T19:24:04Z | |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Exposure Epidemiology and Risk Program | en_US |
dc.identifier.doi | 10.1289/ehp.9074 | * |
dash.contributor.affiliated | Zanobetti, Antonella | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |